AstraZeneca Secondment for Clinical Pharmacology Training

此计划将资助一名实习医生在生物制药行业进行为期9个月的临床试验。国民保健制度的实习医生必须按照培训课程的规定接受专业培训。然而，一些与临床试验相关的培训活动在NHS设置中不容易获得。生物制药行业在设计和运行早期临床试验方面拥有丰富的经验，因此这是进行培训的理想环境。制药公司阿斯利康（AstraZeneca）提供了一个为期9个月的实习医生。这将涉及与临床项目团队合作，以获得涉及设计，设置和运行早期临床试验的一系列活动的经验。该试验将着眼于药物的安全性和有效性，以治疗导致肝脏的血管血压升高。这通常是由肝硬化引起的。20多年来，该疾病领域没有新的治疗方法，即使使用现有的治疗方法，并发症发生率也很高，因此这是一项重要的试验。除了提供临床试验经验外，这种安置还将为新药的整个开发途径提供更广泛的途径。还将有机会通过广泛的科学会议和活动，以及领导和管理培训，与其他早期职业研究人员进行互动。通过这种方式，实习为学员的技能、知识和专业网络的发展创造了一个独特的机会，这将增加他们对下游职业的选择。作为回报，实习医生将通过在阿登布鲁克医院的NHS工作，为行业带来专业知识和临床洞察力。这将在设计和运行心血管和肝脏疾病的拟议临床试验时非常有用。由于地理位置近，这将为阿斯利康大学、剑桥大学和NHS在剑桥共同发展专业技能和人才创造一个独特的机会。通过鼓励员工调动和不同部门之间的知识分享，这将反过来促进实习医生的职业发展。总的来说，这些因素与UKRI创新学者计划的目标密切相关，为更广泛的生物医学科学部门带来一系列好处。

This proposal will provide funding for a trainee doctor to spend 9 months working on clinical trials in the biopharmaceutical industry. Trainee doctors in the NHS are required to undertake specialist training as set out in a training curriculum. However, a number of training activities related to clinical trials are not easily accessible within an NHS setting. The biopharmaceutical industry has a wealth of experience of designing and running early phase clinical trials, so this is an ideal setting in which to undertake training. The pharmaceutical company AstraZeneca (AZ) has offered to host a trainee doctor for a 9 month placement. This would involve working with a clinical project team to gain experience in a range of activities involved in the design, set up and running of an early phase clinical trial. The trial in question would look at the safety and effectiveness of drugs to treat increased blood pressure in the blood vessels that lead to the liver. This is often caused by liver cirrhosis. There have been no new treatments in this disease area for over 20 years and complication rates are high even with existing treatments, so this is an important trial.In addition to providing clinical trial experience, this placement will also provide wider access to the whole development pathway for new medicines. There will also be opportunities to interact with other early career researchers through a wide range of scientific meetings and events, plus leadership and management training. In this way, the placement creates a unique opportunity for growth of the trainee's skills, knowledge and professional network which will enhance downstream career choices. In return, the trainee doctor would bring to industry specialist expertise and clinical insight gained through working within the NHS at Addenbrooke's Hospital. This will be extremely useful when designing and running the proposed clinical trial for cardiovascular and liver disease.With their close geographical location, this placement will create a unique opportunity for AZ, the University and the NHS to work together in Cambridge to develop professional skills and talent. By encouraging transfer of staff and sharing of knowledge between different sectors, it will, in turn, promote career development for the trainee doctor. Collectively, these factors align closely with the aims of the UKRI Innovation Scholars programme bringing a range of benefits to the wider biomedical sciences sector.