EFFECT OF GENDER ON SUBSTRATE UTILIZATION DURING SUBMAXIMAL EXERCISE

关注异常代谢状况的研究增加，即，糖尿病，以及那些可能导致代谢改变偏离已被描述为正常的情况的病症，即，衰老，需要仔细检查性别差异的底物利用和激素反应代谢压力。 因此，本项目的目的是研究在长时间的次极量运动模式中碳水化合物和脂质利用的性别差异。葡萄糖、游离脂肪酸和甘油的稳定同位素示踪剂将用于确定底物动力学。 此外，将通过间接量热法计算底物氧化。 测量的儿茶酚胺，以及胰岛素，将有助于提供深入了解任何性别差异的底物配置文件，可能会在运动过程中发展。该项目的研究结果将有助于更好地理解代谢紊乱的性别特异性反应，并提供信息，作为在代谢研究中使用女性的基础。

The increase in studies focusing on aberrant metabolic conditions, i.e., diabetes, and those conditions which may cause metabolic alterations away from what has been described as normal, i.e., aging, necessitates the careful examination of gender differences in substrate utilization and hormone response to metabolic stress. It is therefore, the intent of this project to examine the gender differences in carbohydrate and lipid utilization during a prolonged submaximal exercise paradigm. Stable-isotopic tracers for glucose, free fatty acids, and glycerol will be used to determine substrate kinetics. In addition, substrate oxidation will be calculated from indirect calorimetry. Measurements of catecholamines, as well as insulin, will help to provide insight into any gender differences in substrate profiles which may develop during exercise. The findings from this project will add to the greater understanding of gender specific rresponse to metabolic perturbation, and provide information to serve as a basis for using women in metabolic studies.