DISORDERS OF LIPID METABOLISM

该方案用于获得血浆脂蛋白和载脂蛋白，以支持格莱斯顿心血管疾病研究所的一些研究项目。这些项目包括与血浆脂蛋白代谢、动脉粥样硬化和神经细胞功能相关的研究。目前的项目旨在检验这一假设，即载脂蛋白-E的三种主要亚型之间的一级结构差异(氨基酸序列差异)解释了不同的三级结构，这些结构影响了脂蛋白代谢中的异构体功能。

This protocol is used to obtain plasma lipoproteins and apolipoproteins to support a number of research projects in the Gladstone Institute of Cardiovascular Disease. The projects include investigations related to plasma lipoprotein metabolism, atherosclerosis, and neural cell function. The current project is designed to test the hypothesis that primary structure differences (amino acid sequence differences) between the three major isoforms of apolipoprotein-E account for different tertiary structures that affect isoform function in lipoprotein metabolism.