SALT SENSITIVITY IN NORMOTENSIVE AFRICAN AMERICANS

[摘要不由PI提供]在血压正常的非裔美国人中，我们将确定：7血压正常的黑人是否会诱发盐敏感现象，分别取决于饮食中钾的摄入量是否略低于正常水平。7血压正常的盐敏感性现象是否与以滤过分数增加为特征的肾脏血流动力学紊乱有关，以及当正常高钾饮食摄入量阻止盐敏感性表达时，是否可以阻止这种增加。7无论是在盐敏感者中：a)饮食中的柠檬酸钠负荷引起升压反应或肾脏血流动力学紊乱；b)饮食中的Cl-As KCl负荷增加了由氯化钠负荷引起的肾脏血流动力学紊乱的任何部分。7交感应激是否增强盐敏感性或相关肾脏血流动力学安排的任何部分，以及饮食中的钾是否调节任何此类增强。7无论是在盐敏感者中，饮食中的钾调节盐诱导的微量蛋白尿。

[Abstract not provided by PI] SPECIFIC AIMS In normotensive African-Americans, we will determine: 7 Whether the phenomenon of salt-sensitivity is or is not evoked in normotensive blacks, depending on whether the dietary intake of potassium is marginally deficient or high-normal, respectively. 7 Whether the phenomenon of normotensive salt-sensitivity is associated with a renal hemodynamic derangement that is characterized by an increased filtration fraction and whether that increase is prevented when a high-normal dietary intake of potassium prevents expression of salt-sensitivity. 7 Whether in those who are salt-sensitive: a) dietary loading of sodium citrate elicits either a pressor response or renal hemodynamic derangement; and b) dietary loading of Cl- as KCl augments any part of the renal hemodynamic derangement induced by NaCl loading. 7 Whether sympathetic stress augments either salt-sensitivity or any part of the associated renal hemodynamic arrangement, and whether dietary potassium modulates any such augmentation.. 7 Whether in those who are salt-sensitive, dietary potassium modulates salt-induced microalbuminuria.