课题基金 / 基金详情

GANCICLOVIR/CIDOFOVIR CMV RETINITIS TRIAL

GANCICLOVIR/CIDOFOVIR CMV RETINITIS TRIAL
更昔洛韦/西多福韦 CMV 视网膜炎试验
批准号：
6291129
负责人：
JOSEPH WHEAT
金额：
$0.04万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6291129
关键词：
AIDS antiviral agents clinical research clinical trials cytomegalovirus retinitis eye disorder chemotherapy ganciclovir human subject human therapy evaluation

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中文摘要
翻译
更昔洛韦和西多福韦CMV视网膜炎试验(GCCRT)是对两种不使用中心静脉导管治疗新诊断和复发的艾滋病相关CMV视网膜炎的治疗方案的研究。这两种方案是：1)更昔洛韦眼内装置联合口服更昔洛韦；2)静脉注射西多福韦。这项试验的主要目的是比较最新的巨细胞病毒视网膜炎药物西多福韦与常用的治疗方案更昔洛韦眼内装置加口服更昔洛韦在预防视力丧失方面的有效性。第二个目标是比较结合了高活性局部疗法(更昔洛韦装置)的治疗方案和不含高活性局部疗法的治疗方案。
英文摘要
The Ganciclovir and Cidofovir CMV Retinitis Trial (GCCRT) is a study of two treatment regimens that are administered without the use of a central venous catheter for both newly diagnosed and relapsed AIDS-related CMV retinitis. The two regimens are: 1) ganciclovir intraocular device plus oral ganciclovir and 2) intravenous cidofovir. The primary objective of the trial is to compare the newest CMV retinitis drug, cidofovir, to a commonly used treatment regimen, the ganciclovir intraocular device plus oral ganciclovir, with respect to efficacy in preventing vision loss. A secondary objective is to compare a treatment regimen that incorporates highly active local therapy (the ganciclovir device) with a treatment regimen that does not.
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