METHODS FOR ASSESSING MEDICATIONS TO LOWER ETOH: INTAKE FIELD STUDY

这项研究的主要目的是开发评估药物导致人类酒精摄入量减少的行为机制的方法。尽管新的药物正在被引入来控制酗酒者的酒精摄入量，但人们对这些药物实际上是如何改变酒精对人体的影响知之甚少。这项研究的目的是开发一种行为评估组件，以测量社交饮酒者在野战酒精自我给药过程中的冲动和刺激。这些刺激和冲动的行为措施的有效性将在社交饮酒者中进行评估，预先给予三种剂量的纳曲酮之一。纳曲酮是FDA批准的一种降低酒精消耗的药物疗法。

The primary aim of the research proposed to develop methods for assessing the behavioral mechanisms underlying medication-induced decreases in alcohol intake in humans. Although new medications are being introduced to control alcohol intake in alcoholics, little is known about how these medications actually change the effects of alcohol in people. The purpose of this study is to develop a behavioral assessment battery to measure urge and stimulation in social drinkers during a field alcohol self-administration protocol. The utility of these behavioral measures of stimulation and urge will be assessed in social drinkers, pretreated with one of three doses of naltrexone. Naltrexone is an FDA approved pharmacotherapy for lowering alcohol consumption.