课题基金 / 基金详情

STEM CELL MOBILIZATION AND HARVESTING FROM THE PERIPHERAL BLOOD

STEM CELL MOBILIZATION AND HARVESTING FROM THE PERIPHERAL BLOOD
干细胞的动员和从外周血中收获
批准号：
6118432
负责人：
STEVEN MILES
金额：
$0.19万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6118432
关键词：
HIV infections cell motility cellular immunity clinical research glia helper T lymphocyte hematopoietic stem cells human immunodeficiency virus human subject immunopathology monocyte neuroimmunomodulation opportunistic infections phenotype virus replication

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中文摘要
翻译
HIV-1感染的特征是进行性免疫功能障碍，最终导致一种或多种机会性感染，这些感染与细胞免疫的严重缺陷有关。这种免疫衰竭是病毒在CD4+表面表型的淋巴细胞以及单核细胞和神经胶质细胞中复制的结果。
英文摘要
HIV-1 infection is characterized by progressive immunologic dysfunction that ultimately results in one or more opportunistic infections that are associated with profound defects in cellular immunity(1). This immunologic depletion is the result of viral replication in lymphocytes of the CD4+ surface phenotype as well as in cells of monocyte and glial origin.
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