DETERMINATION OF 3 D STRUCTURE OF SORBITOL DEHYDROGENASE

山梨醇脱氢酶，也称为葡糖醇、多元醇或 L-艾迪醇脱氢酶催化山梨醇氧化成 果糖和NAD作为辅因子。它已经在广泛的地方被检测到 各种动物、植物和微生物。活动能力减退 SDH，导致山梨醇在细胞内积累，已被 与脑水肿和糖尿病的病因学有关 多发性神经病。山梨醇脱氢酶的结构信息 可以用来设计抑制剂和药物。

Sorbitol dehydrogenase, also known as glucitol, polyol, or L-iditol dehydrogenase, catalyzes the oxidation of sorbitol to fructose with NAD as a cofactor. It has been detected in a wide variety of animals, plants and microorganisms. Impaired activity of SDH, resulting in accumulation of sorbitol within cells, has been implicated in the etology of cerebral edema and diabetic polyneuropathy. The structure information of sorbitol dehydrogenase could be used to design inhibitors and drugs.