GELSOLIN W/ PIP2 BOUND

凝溶胶蛋白是一种肌动蛋白结合蛋白， 帽和成核肌动蛋白丝。 凝溶胶蛋白被激活， 钙和肌动蛋白/凝溶胶蛋白复合物被解离， 聚肌醇磷酸。 在这项研究中，我们建议解决 与聚肌醇磷酸类似物结合的凝溶胶蛋白的结构 我们的目标是了解凝溶胶蛋白活性的调节。

Gelsolin is an actin binding protein that is capable of severing, capping and nucleating actin filaments. Gelsolin is activated by calcium and actin/gelsolin complexes are dissociated by polyinositolphosphates. In this study we propose to solve the structure of gelsolin bound to polyinositolphosphate analogues with the goal of understanding this regulation of gelsolin activity.