PROTEIN INTERACTIONS IN APOPTOSIS

细胞程序性死亡(PCD)和细胞凋亡是两个重要的过程 自我更新的组织。当这个正常的监管系统 如果结果被破坏，可能会导致几种疾病，包括 癌症。因此，细胞凋亡途径提供了一条有趣的途径 干预该病的发病机制。Bcl2家族的研究进展 蛋白质是关键的调节分子，可以促进或 通过一种复杂的模式抑制细胞死亡途径 蛋白质之间的相互作用。我们已经结晶了一种蛋白质袋子-1 它能与Bc l-2结合，并增强其抗凋亡活性 BCL-2。目标是了解这种蛋白质的分子基础。 在细胞凋亡中的关联并生成原子模型来揭示 相互作用的表面和/或构象变化 分子触发了细胞的凋亡反应。

Programmed cell death (PCD) and apoptosis are important processes of self-renewing tissues. When this normal regulatory system is disrupted, the results can contribute to several diseases including cancer. Therefore the apoptotic pathway offers an intriguing avenue to intervene in the pathogenesis of the disease. The Bcl-2 family of proteins are critical regulatory molecules that either promote or repress the cell death pathway through a complex pattern of protein-protein interactions. We have crystallized a protein BAG-1 that binds to Bcl-2, and enhances the anti-apoptotic activity of Bcl-2. The goal is to understand the molecular basis for the protein associations in apoptosis and to generate atomic models to reveal interacting surfaces and/or conformational changes that may serve as molecular triggers in the apoptotic response.