REGULATION OF HEPATIC LPS BINDING PROTEIN PRODUCTION

需要支持高级计算资源进行研究 蛋白质和多肽的折叠和热力学。关注的一个领域是 螺旋传播310个螺旋。这些研究将有助于深入了解 蛋白质初始阶段的二级结构形成 折叠。蛋白质折叠的早期阶段将通过 螺旋蛋白质中多肽片段的表征。研究 肌红蛋白的蛋白质折叠和蛋白质的免疫球蛋白结合素域 G将被制造出来。与实验和理论模型的比较 因为蛋白质折叠将遵循实验的计算 与酰胺H/D交换有关的可观测光谱性质 保护和圆二向色性。我们还计划继续 开发异质耦合计算模型，这将使 高效使用Cray YMP C90和大规模并行T3D 架构，以及只专注于T3D。

Support is requested for advanced computing resources to study protein and peptide folding and thermodynamics. One area of focus is helix propagation 310 helices. These studies will lend insight into secondary structure formation in the initial stages of protein folding. Early stages in protein folding will be explored through the characterization of peptide fragments from helical proteins. Studies of protein folding for myoglobin and the IGg bindin domain of protein G will be made. Comparisons with experiment and theoretical models for protein folding will follow through calculations of experimentally observable spectroscopic properties related to amide H/D exchange protection and circular dichroism. We also plan to continue to develop heterogeneous coupled computational models which will make efficient use of the Cray YMP C90 and the massively parallel T3D architecture as well as focusing on the T3D alone.