Development of potent and selective blockers of acid sensing ion channels for the treatment of pain

超过300万澳大利亚人患有慢性疼痛，而治疗这种疾病的有效药物却很少。2007年的一份经济报告估计，澳大利亚慢性疼痛的经济负担为343亿美元。酸感应离子通道（asic）是最近发现的在痛觉中起关键作用的蛋白家族。该项目的目标是开发这些通道的有效阻滞剂，可用于治疗患有持续性疼痛的患者。

More than three million Australians suffer from chronic pain, and there are few effective drugs available for treating this condition. A 2007 Access Economics Report estimated the economic burden of chronic pain in Australia at $34.3 billion. Acid-sensing ion channels (ASICs) are a recently discovered family of proteins that play a key role in sensing pain. The goal of this project is to develop potent blockers of these channels that can be used to treat patients suffering from persistent pain.