COMPUTER SIMULATION MODELING OF SOMATOSENSORY CORTEX

该提案是对25个服务单位的续订请求，这些服务单位将 允许我们继续生理实验的相互作用 和计算机模拟，这是我们从1989年以来一直在进行的。在过去的时间里 年我们在建立大脑皮层网络模型方面所做的努力 体感信息处理已被证明在指导我们的 实验的选择。我们目前正在写一系列的三个 关于阿司匹林对皮层神经元影响的文章 抑制性受体激动剂的微离子电泳法应用 拮抗剂及其计算机模拟。第一篇论文涉及 用皮质层IV得到的结果与抑制 神经递质GABA和GABAA受体荷包牡丹碱 亚型拮抗剂。第二篇文章比较了两种方法的异同 在第IV层和上下各层之间产生了荷包牡丹线 它和第三个处理使用GABAB受体获得的数据 拮抗剂，巴氯芬。未来的实验和模拟， 将包括使用激动剂的微离子电泳法研究 神经递质谷氨酸，以及我们1992年提出的 尚未执行的请求。

This proposal is a renewal request for 25 service units that will allow us to continue the interplay of physiological experimentation and computer simulation that we've pursued since 1989. Over the past year our efforts at modeling cerebral cortical networks engaged in somatosensory information processing have proven useful in guiding our choice of experiments. We currently are writing a series of three articles concerning the effects on cortical neurons of microiontophoretic application of inhibitory receptor agonists and antagonists, and computer simulations thereof. The first paper deals with cortical layer IV results obtained with the inhibitory neurotransmitter GABA, and bicuculline methiodide, a GABAa receptor subtype antagonist. The second paper deals with a comparison of bicuculline results between layer IV and the layers above and below it, and the third deals with data obtained using the GABAb receptor antagonist, baclofen. Future experiments, and simulations thereof, will include microiontophoretic studies using the excitatory neurotransmitter glutamate, as well as ones proposed in our 1992 request that haven't yet been performed.