ARTHRITIS AND IMMUNOLOGY

本研究培训计划提供五个博士后和三个博士后实习生职位，其主要目的是为研究风湿病的发病机制提供广泛的免疫学和分子生物学方面的研究经验。与过去一样，对规划风湿病学术生涯的医学博士后研究员的培训受到了主要重视。博士前候选人，主要是微生物学/免疫学系的博士前候选人受到了重点关注。博士前候选人，主要是微生物学/免疫学系，可以选择风湿病和免疫学分部的教员作为导师，使基础免疫学家的发展能够将他们的研究培训应用于风湿病领域的相关问题。培训计划在很大程度上是先导性的，受训者75%以上的时间用于基础和临床研究人员实验室的独立研究活动，他们主要来自风湿病和免疫学系和微生物/免疫学系，正在进行的动物和人类研究包括许多与自身免疫、关节炎和肌肉骨骼疾病相关的问题：正常和异常免疫反应中识别元件的遗传、调节和功能；细胞因子和炎症反应基因的诱导和调节；自身抗体对疾病发病机制的贡献；细胞凋亡；自身免疫的适应症；实验性关节炎；软骨和软骨降解产物的生物化学；机械性关节损伤的病理生理学及其与骨关节炎的关系；临床研究。学员研究得到现代分子和细胞免疫学所有必要设备和资源的支持，例如DNA和蛋白质测序、寡核苷酸和多肽合成、流式细胞术和细胞分选、高效液相、氢化物产生、免疫化学调查和各种定量分析(放射免疫分析和ELISA法)，以及近交系小鼠的维护。此外，还可提供用于培养基制备、细胞系、组织培养、超速离心法、放射性核素计数等的核心1单元。微生物学/免疫学、生物化学和生物物理系的整个课程，以及向学员开放的医学院系，分子生物学项目提供的特殊实验室课程也是如此。此外，风湿病研究员可以选择参加罗伯特·伍德·约翰逊临床学者计划提供的一个学期的生物识别课程，并受益于与瑟斯顿关节炎研究中心数值科学核心单位的教师的密切互动。博士后研究员还需要参加各种定期的研讨会和教学会议，包括风湿学大轮回、免疫学期刊俱乐部，以及每周一次的研究进展会议，受训人员在会上介绍他们的研究。博士前实习生的课程是根据他们的需求量身定做的。

DESCRIPTION Five postdoctoral and three pre-doctoral trainee positions are proposed in this research training program, the thrust of which is to provide a broad investigational experience in immunology and molecular biology basic to the study of the pathogenesis of rheumatic diseases. As in the past, the training of MD post-doctoral fellows who plan careers in academic rheumatology receives major emphasis. Pre-doctoral candidates, primarily in the Department of Microbiology/Immunology receives major emphasis. Pre-doctoral candidates, primarily in the Department of Microbiology/Immunology, may select faculty in the Division of Rheumatology and Immunology as mentors, enabling the development of basic immunologists who can apply their research training to questions of relevance t o the field of rheumatology. The training program is largely preceptorial, with more than 75% of the trainee's time devoted to independent research activities in the laboratories of basic and clinical investigators on the faculty, who are drawn primarily from the Division of Rheumatology and Immunology and the Department of Microbiology/Immunology, Ongoing animal and human research encompasses many of the issues relevant to autoimmunity, arthritis , and musculoskeletal disease genetics, regulation ,and function of recognition elements in normal and abnormal immune responses; induction and regulation of cytokine and inflammatory response genes; contribution of autoantibodies to diseases pathogenesis; apoptosis; indication of autoimmunity; experimental arthritis; biochemistry of cartilage and cartilage degradation products; pathophysiology of mechanical joint injury and its relationship to osteoarthritis; and clinical investigation. Trainee research is supported by all of the necessary equipment and resources for modern molecular and cellular immunology, e.g., facilities for DNA and protein sequencing, synthesis of oligonucleotide sand peptides, flow cytometry and cell sorting, HPLC, hydridoma production , immunochemical investigations, and various types of quantitative assays (radioimmunoassays and ELISA), and the maintenance of >60 strains of inbred mice. Core 1 units for media preparation, cell lines, tissue culture ultracentrifugation, radionuclide counting, etc, are available as well. The entire curriculum in the Departments of Microbiology/Immunology, Biochemistry and Biophysics, and the medical school departments i open to trainees, as are special laboratory courses offered by the Program in Molecular Biology. In addition, rheumatology fellows may elect to take a semester course in biometrics offered by the Robert Wood Johnson Clinical Scholars program and benefit from close interaction with faculty in the Numerical Sciences Core Unit of Thurston Arthritis Research Enter. Post-doctoral fellows also are required to participate in a variety of regular seminars and teaching conferences, including Rheumatology grand Rounds, an immunology journal club, and a weekly research-in-progress conference where trainees present their research. The curriculum for pre-doctoral trainees is tailored to their needs.