High-Resolution Preclinical Multimodal PET/SPECT/CT Nuclear Imaging System

核成像是医学成像的一个分支，它使用少量的放射性物质来诊断和治疗各种疾病。核成像的重点不是解剖，而是基于功能。放射性示踪剂被设计成被特定的细胞过程主动吸收，以提供疾病的生理病理学信息。例如，与正常细胞相比，放射性葡萄糖是一种被高度复制的癌细胞吸收的糖，使我们能够区分良性和肿瘤性病变。核成像分为两个成像学科;单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET），每一个都有自己的优势，放射性示踪剂的发展，以确定特定的疾病生理。这些三维成像技术与计算机断层扫描（CT）相结合，CT是一种使用特殊X射线设备来创建身体内部区域的详细图片的程序，用于定位。在该应用中，我们要求一种高灵敏度的多模式PET/SPECT/CT系统，其中可以放置活小鼠。该设备将使我们能够跟踪放射性标记的药物、分子和细胞，以提供有关疾病状态下器官功能的宝贵数据，并为心血管疾病、神经系统疾病和癌症等不治之症找到新的治疗方法。

Nuclear imaging is a branch of medical imaging that uses small amounts of radioactive material to diagnose and treat a variety of diseases. The emphasis of nuclear imaging is not anatomical but based on function. Radioactive tracers are designed to be actively taken up by a specific cell process to provide information of the physiological pathology of a disease. For example radioactive glucose is a sugar taken up by highly replicating cancer cells compared to normal cells allowing us to distinguish between benign and tumorous lesions. Nuclear imaging is broken down into two imaging disciplines; Single photon emission computed tomography (SPECT) and positron emission tomography (PET), each have their own advantages for radioactive tracer development for identifying specific disease physiology. These three-dimensional imaging techniques are combined with computerized tomography (CT), a procedure that uses special x-ray equipment to create detailed pictures of the areas inside the body, for localization. In this application we request a highly sensitive multimodal PET/SPECT/CT system into which live mice can be placed. This equipment will allow us to follow radioactively labelled drugs, molecules, and cells to provide invaluable data on the function of organs in disease states and find new treatments for incurable diseases such as cardiovascular disease, neurological disorders and cancer.