Next Generation Flow Cytometry: Establishing Spectral Flow Cytometry to Revolutionise High Dimensional Analysis in Animal Models and Patient Cohorts

我们的身体由许多不同类型的细胞组成，这些细胞执行不同的功能。如果这些细胞没有正确地相互作用，就可能导致疾病。了解细胞相互作用是如何出错的，对于理解所有人类疾病都很重要。这个应用程序的目的是购买一台新的机器，一种光谱流式细胞仪，它可以让我们观察许多细胞是如何同时作用的。曼彻斯特大学的所有研究人员都可以通过流式细胞术设备使用这台机器。光谱流式细胞仪是一种新型技术，它允许同时测量每个细胞的更多特性和功能，而不是以前可能的(67个特性/功能)。来自血液或组织(如肺)的单个细胞迅速通过悬浮在液体中的流式细胞仪，从而在几分钟内获得数百万细胞的信息。整个大学的研究人员将使用这台机器来了解炎症性疾病和感染中的细胞是如何出错的，以及如何使用药物来针对特定的免疫细胞群体。

Our bodies are composed of lots of different types of cells that perform different functions. If these cells don't interact properly this can lead to disease. Understanding how cell interactions go wrong is important to understand all human diseases. The purpose of this application is to buy a new machine, a spectral flow cytometer, that allows us to look at how lots of cells are acting simultaneously. This machine will be accessible to all researchers at The University of Manchester through the Flow Cytometry Facility. A spectral flow cytometer is a new type of technology that allows more characteristics and functions of each cell to be measured at the same time than was previously possible (67 characteristics/functions). Individual cells from the blood or from tissues, such as the lung, run through the flow cytometer suspended in liquid very rapidly allowing for information on millions of cells to acquired in a matter of minutes. Researchers across the University will use the machine to understand how cells go wrong in inflammatory diseases and infections and how drugs might be used to target specific immune cell populations.