ROUTES TO CHIRAL CARBOCYCLIC AND HETEROCYCLIC COMPOUNDS

在过去的十几年里，通过探索手性、非外消旋双环内酰胺类化合物的化学而取得的非凡成功，需要我们再继续一年的研究。我们已经发表了75篇关于这一非凡的手性环系统的论文和4篇评论，随着我们继续深入了解这一化学，出现了几个新的方向。在这个最后的继续要求中，我们将描述一些重要的手性杂环(哌啶类、吡咯烷类、氮杂环类)以及多功能碳环的化学，它们的结构很快就表明它们可以用来合成各种生物重要的化合物。

The extraordinary success realized by probing the chemistry of chiral, non-racemic bicyclic lactams over the past dozen years requires us to continue the investigation for one more year. We have published over 75 papers and four reviews on this remarkable chiral ring system and as we proceed to wind down this chemistry, several new directions appear. In this final continuation request we will describe chemistry which will access a number of important classes of chiral heterocycles (piperidines, pyrrolidines, azepines) as well as multifunctional carbocycles whose architecture quickly suggest they can be used to reach a variety of biologically important compounds.