MRC Centre for Global Infectious Disease Analysis (MRC GIDA)

2019冠状病毒病大流行清楚地说明了新发传染病可能对健康和社会产生的潜在影响。因此，为未来的威胁做好更好的准备是全球公共卫生机构和政府的一个关键优先事项。与此同时，必须继续努力减轻传染病造成的疾病和死亡负担，因为传染病继续困扰着许多国家，特别是那些收入和资源较低的国家。科学家在支持这些更广泛的倡议方面可以发挥关键作用。除了开发针对特定疾病的新药或疫苗外，科学还可以帮助了解如何最好地使用这些新工具，它们将在何处发挥最大效益，以及需要什么来实现更广泛的消除目标。我们的全球传染病分析中心对一系列传染病进行流行病学研究，重点是应用这些研究来帮助为公共卫生控制提供信息。中心的一个主要特点是我们的翻译工作；我们与英国的公共卫生机构（如英国卫生安全局）和国际上（包括作为世界卫生组织的合作中心）密切合作，帮助解决他们发现的问题，并提供信息，帮助他们向政府和地方机构提供建议。通过我们撰写的报告和为支持决策而生成的信息，全球都可以清楚地看到我们支持COVID-19大流行应对的工作。然而，与此同时，我们还继续在艾滋病毒、结核病和疟疾等主要全球疾病方面开展工作，帮助了解如何最大限度地利用有限的资源来减少病例和死亡。中心的目标将是继续支持更广泛的活动，这些活动汇集了中心科学家开展的基础科学，以确保我们的产出能够转化为支持公共卫生决策。为此，我们将把我们的研究集中在四个主题领域：1)准备和应对新出现的威胁；二)全球卫生；Iii)疫苗和疗法（药物或新的单克隆抗体疗法）和iv)基因组和流行病学数据之间的交集。通过这样做，我们将把研究不同疾病的团体聚集在一起，考虑采取综合办法来解决这些全球性问题。我们还将与其他科学家和更广泛的学术界广泛合作，将影响社会的更广泛问题纳入考虑，以评估它们对传染病的影响——包括气候和环境的变化、根据大流行作出的行为反应以及经济学。我们还将在三个方面开展工作，以实现我们的科学的翻译和交流：1。通过支持一个软件工程师团队，他们将帮助建立可持续的、开源的计算机代码，以及我们模型的用户友好界面，支持它们在科学界和更广泛的范围内得到更广泛的吸收。2 .通过创建一个“转化模型中心”，重点为公共卫生合作伙伴提供产出，并支持在全社会范围内更广泛地传播活动。支持培训，包括研究生教育、针对（联合王国和国外）公共卫生专业人员的短期课程，以及通过我们的全球学术和公共卫生伙伴网络加强流行病学方面的能力。

The COVID-19 pandemic has clearly illustrated the potential impact that emerging infectious diseases can have on health and on society. Being better prepared for future threats is therefore a key priority for public health agencies and governments globally. At the same time, it is important that efforts continue to decrease the burden of illness and death from infectious diseases that continue to plague many countries - particularly those with lower income and resources. Scientists have a key role to play in supporting these wider initiatives. As well as developing new drugs or vaccines for specific diseases, science can also help to understand how these new tools should best be deployed, where they will have maximum benefit and what is needed to achieve broader goals of elimination. Our Centre for Global Infectious Disease Analysis undertakes epidemiological research across a range of infectious diseases, with a focus on applying these to help inform public health control. A key feature of the Centre is our translational work; we collaborate closely with public health agencies in the UK (such as the UK Health Security Agency) and internationally (including as a Collaborating Centre with the World Health Organisation) to help address questions that they have identified and to provide information that helps them to provide advice to governments and local agencies. Our work supporting the COVID-19 pandemic response was clearly visible globally through the reports that we contributed and the information that we generated to support decision-making. However, alongside this we also continue to work on key global diseases - such as HIV, tuberculosis and malaria - helping to understand how limited resources can be used to greatest effect to reduce cases and deaths. The aim of the Centre will be to continue to support the broader activities that bring together the underpinning science undertaken by Centre scientists in order to ensure that our outputs can be translated to support public health decisions. To do this we will bring together our research under four thematic areas - i) preparedness and response to emerging threats; ii) global health; iii) vaccines and therapeutics (drugs or new monoclonal antibody treatments) and iv) the intersection between genomic and epidemiological data. By doing so, we will bring together groups working on different diseases to consider a combined approach to tackling these global issues. We will also collaborate extensively with other scientists and the wider academic community to factor in broader issues affecting societies to evaluate their impact on infectious diseases - including changes in climate and the environment, behavioural responses in light of the pandemic, and economics. We will additionally work in three areas to enable the translation and communication of our science: 1. By supporting a team of software engineers who will help to build sustainable, open-source computer code as well as user-friendly interfaces to our models, supporting their wider uptake within the scientific community and more broadly.2. By creating a "Translational Modelling Hub" focused on generating outputs for public health partners, and also supporting the wider communication of activities across society.3. Supporting training including postgraduate education, short-courses aimed at public health professionals (in the UK and abroad) and capacity-strengthening in epidemiology through our global network of academic and public health partners.