UW-FHCRC VARIATION DISCOVERY RESOURCE

炎症是与多种疾病相关的最基本反应之一， 常见的人类疾病，包括哮喘、慢性阻塞性肺疾病 疾病、冠状动脉疾病和中风。 在本申请中， 调查人员建议华盛顿大学和 弗雷德哈钦森癌症研究中心（UW-FHCRC）建立一个变异 发现资源（VDR）专注于寻找单核苷酸多态性 （SNPs）在人类炎症反应的基因和途径。 目标是：（1）建立一个高通量的变异发现组 它将扫描200多个与炎症有关的基因;（2） 确定共同的可变位点，它们的相对频率和单倍型 在这些基因的两个群体具有不同的进化历史; (3)通过以下方式迅速向生物医学界传播这一信息 国家数据库，如dbSNP和Genbank，并通过产生的资源 （4）建立一个培训和教育计划， 变化分析，提供现场培训以及正式的 车间 总的来说，这些研究将提供丰富的新信息， 测试人类DNA变异之间存在的重要关系 序列和常见人类疾病风险的变化。(End摘要）

Inflammation is one of the most basic responses linked to a wide variety of common human disorders including asthma, chronic obstructive pulmonary disease, coronary artery disease and stroke. In this application, the investigators propose a joint program between the University of Washington and the Fred Hutchinson Cancer Research Center (UW-FHCRC) to establish a Variation Discovery Resource (VDR) focused on finding single nucleotide polymorphisms (SNPs) in the genes and pathways underlying inflammatory responses in humans. The goals are: (1) to establish a high throughput variation discovery group that will scan more than 200 of the genes involved in inflammation; (2) to identify the common variable sites, their relative frequencies, and haplotypes in these genes for two populations having different evolutionary historics; (3) to rapidly disseminate this information to the biomedical community via national databases such as dbSNP and Genbank, and by a resource generated website; and (4) to establish a training and education program on human variation analysis that provides on-site training as well as a formalized workshop. Overall, the studies will provide a wealth of new information for testing the important relationships that exist between variations in human DNA sequence, and variations in risk for common human diseases. (End of Abstract)