THE SLEEP HEART HEALTH STUDY

睡眠心脏健康研究（SHHS）始于1994年，是一项关于睡眠呼吸障碍（SDB）心血管后果的多中心队列研究。 该研究的主要目的是评估SDB作为不良心血管结局的危险因素，包括冠心病事件、中风和高血压，以及血压随年龄的加速升高。 SHHS方案在正在进行的心血管和其他疾病的队列研究中增加了SDB评估，包括Frachial Offspring和Omni队列，社区动脉粥样硬化风险（AMC）研究的哈格斯敦和明尼阿波利斯/圣保罗研究中心，心血管健康研究（CHS）的哈格斯敦、萨克拉门托和匹兹堡研究中心，南达科他州、俄克拉荷马州和亚利桑那州的强心研究（SHS）研究中心以及图森市呼吸系统疾病和纽约高血压的队列研究。 在头四年（1994-1998年），SHHS成功启动，从6，440名参与者家中获得了完整和高质量的多导睡眠图（PSG）数据，超过了招募目标。 SHHS队列包括3，039名男性和3，401名40岁或以上的女性，其中8.2%是非洲裔美国人，9.6%是美洲原住民，1.3%是亚洲人，4.2%是西班牙裔。 除PSG外，数据收集还包括打鼾和嗜睡以及生活质量（QOL）。 所有队列的结果评估方案都已到位，第二次SHHS检查正在进行中。初步的横断面调查结果显示，SDB是常见的，并与高血压和自我报告的心血管疾病（CVD）。 该应用程序要求五年的额外支持，以继续SHHS。需要进一步随访以获得足够的把握度来检验主要SHHS假设。 此外，在第8-9年，将重复PSG，以进一步表征参与者的SDB并描述SDB的自然史。 在最初的五年里，SHHS已经表明，可以在社区中进行大规模的睡眠，SDB和疾病风险研究。SHHS队列的随访将提供描述SDB的心血管后果所需的数据，沿着其自然史。 该提案是一项资助SHHS亚利桑那大学现场中心的请求，以履行其在这项多中心研究中对909名参与者进行重复PSG和心血管随访的职责。

The Sleep Heart Health Study (SHHS) was started in 1994 as a multicenter cohort study of the cardiovascular consequences of sleep-disordered breathing (SDB). The study's principal aims are to assess SDB as a risk factor for adverse cardiovascular outcomes, including incident coronary heart disease events, stroke, and hypertension, and accelerated increase in blood pressure with age. The SHHS protocol added an assessment of SDB to ongoing cohort studies of cardiovascular and other diseases, including the Framingham Offspring and Omni cohorts, the Hagerstown and Minneapolis/St. Paul sites of the Atherosclerosis Risk in Communities (AMC) Study, the Hagerstown, Sacramento, and Pittsburgh sites of the Cardiovascular Health Study (CHS), the Strong Heart Study (SHS) sites in South Dakota, Oklahoma, and Arizona, and cohort studies of respiratory disease in Tucson and of hypertension in New York. During its first four years (1994-1998), the SHHS was successfully started with full and high quality polysomnography (PSG) data obtained in the home from 6,440 participants, exceeding the recruitment target. The SHHS cohort, includes 3,039 men and 3,401 women 40 years of age or more, of whom 8.2 percent are African American, 9.6 percent are Native American, 1.3 percent are Asian, and 4.2 percent are Hispanic. In addition to PSG, data collection covered snoring and sleepiness and quality of life (QOL). Outcome assessment protocols are in place for all cohorts and the second SHHS examination is now in progress. Initial cross-sectional findings show that SDB is common and associated with hypertension and self-reported cardiovascular disease (CVD). This application requests five years additional support to continue the SHHS. Further follow-up is needed to have sufficient power to test the primary SHHS hypotheses. Additionally in Years 8-9, PSG will be repeated to further characterize SDB in the participants and to describe the natural history of SDB. During the first five years, the SHHS has shown that large-scale research on sleep, SDB, and disease risk can be conducted in the community. Follow-up of the SHHS cohort will provide the data needed to characterize the cardiovascular consequences of SDB, along with its natural history. This proposal is a request to fund the University of Arizona Field Center of the SHHS to fulfill its role performing repeat PSG and cardiovascular follow-up of 909 participants in this multicenter study.