FASEB CONFERENCE ON AMYLOID & OTHER PROTEIN ASSEMBLY

描述（来自摘要）：申请要求部分资金， 支持2000年FASEB关于淀粉样蛋白和其他异常的夏季研究会议 蛋白质组装过程，将于6月在科罗拉多铜山举行 2000年11-16日。这次会议的主要目的是汇集临床医生 和细胞生物学家熟悉异常蛋白质的生物学， 遗传学家、分子生物学家和生物药理学家， 建立对这些现象的分子基础的理解。重点 是淀粉样疾病的分子基础，蛋白质聚集 （特别是淀粉样蛋白和包涵体形成）和其他表现， 蛋白质-蛋白质，以及潜在的干预方法。会议 参加人数以一百五十至一百六十人为限。特邀演讲人将 从这些领域的领导者中选出，特别强调 代表性不足的群体。 会议将包括一个主旨演讲，介绍 淀粉样蛋白，9次正式口头报告会议，以及海报会议 和一个研讨会，其主题将包括蛋白质和β片层 结构，蛋白质折叠过程中的聚集，朊病毒颗粒，临床 主要淀粉样蛋白疾病的概述，淀粉样蛋白形成的结构基础， 肽，AD中的淀粉样蛋白途径，淀粉样蛋白在遗传中的新作用， 研究不溶性蛋白质复合物的物理方法，因子 与体内淀粉样蛋白和新模型生物系统相关。会 也有两个海报会议。FASEB夏季研究的形式 会议是理想的刺激交叉施肥在发展中国家的领域， 研究：会议规模有限，会议日程集中， 与世隔绝的气氛，都鼓励参与者之间的互动。 这一系列会议以前曾举行过两次会议，第一次在1995年， 随后。这里的形式是小的，亲密的，促进密切的讨论。 近期的两个相关会议是（1）索尔克研究所会议 1999年2月，和（2）即将举行的班伯里会议。这些重点是 疾病问题和蛋白质折叠。拟议的FASEB会议结合了 这些主题，包括学生，博士后和初级教师。

DESCRIPTION (from abstract): The application requests partial funding to support the 2000 FASEB Summer Research Conference on Amyloid and Other Abnormal Protein Assembly Processes, to be held at Copper Mountain, Colorado, June 11-16, 2000. The main objective of this meeting is to bring together clinicians and cell biologists familiar with the biology of abnormal protein with geneticists, molecular biologists and biophysicists who will ultimately establish an understanding of the molecular basis of these phenomena. The focus is on the underlying molecular basis of amyloid diseases, protein aggregation (especially amyloid and inclusion body formation) and other manifestations of protein-protein, as well as potential methods of intervention. The conference attendance will be restricted to 150-160 participants. Invited speakers will be chosen from among the leaders in these fields, with particular emphasis on under-represented groups. The conference will consist of a keynote address providing a history of amyloid, nine formal sessions of oral presentations, as well as poster sessions and a workshop session, whose topics will include protein and beta sheet structure, protein aggregation during folding, prion particles, clinical summaries of major amyloid diseases, structural basis of amyloid formation by peptides, the amyloid pathway in AD, new roles for amyloid in heredity, physical methods for the study of insoluble protein complexes, factors associated with amyloid in vivo and new model biological systems. There will also be two poster sessions. The format of the FASEB Summer Research Conferences is ideal for stimulating cross-fertilization in developing areas of research: the limited size of the conference, focused meeting schedule and isolated atmosphere all encourage interactions among the participants. There have been two previous meetings in this series, the first in 1995 and one subsequently. The format here is small, intimate, promoting close discussions. Two related meetings in the near term are (1) the Salk Institute conference in February, 1999, and (2) a forthcoming Banbury conference. These focus on disease issues and on protein folding. The proposed FASEB conference combines these topics and includes students, post-docs and junior faculty.