SPECT MAMMOGRAPHY USING ROTATING SLANT HOLE COLLIMATOR

描述(改编自申请人摘要)：在本申请中， 申请者仔细地阐述了拟议的特殊用途的重要应用。 乳腺癌分期和定性技术。初步结果 包括一个原型的RMSSH准直器。此外，还有一个新的具体目标和 进行拟议技术的初步临床试验的方法是 添加了。提出的SPECTM技术的创新包括：(1)使用 MSSH准直器，其探测效率是 它的视场比传统的准直器具有相同的空间 分辨率，(2)通过以下方式获取全套投影数据的能力 只需在90度圆弧上将MSSH旋转到2到3个位置 乳房，(3)RMSSH准直器靠近乳房的能力 在数据采集过程中获得最佳空间分辨率，以及(4)使用完全的 将完整的投影数据集重建为 提供高质量、定量准确且无伪影的重建 图像。研究设计和研究方法包括：(1)空间设计 用于SPECTM技术的MSSH准直器的优化，(2)研制 用于完整预测的传输和排放数据获取策略 使用旋转MSSH准直器的数据集，(3)发展 全三维重建方法，提供准确的定量 乳房重建图像，(4)3D SPECTM图像的评估 乳房小而低收缩病变的检测和特征， 和(5)SPECTM技术的初步临床评估 病人。提出的新的SPECTM技术可以很容易地在大多数情况下实现 核医学诊所只需要低成本(约2万美元)的RMSSH 准直仪组件。它将提供更好的评估能力 为分期目的乳腺癌的范围和特征 已被发现在乳腺癌的外科治疗中很有用。

DESCRIPTION (Adapted from Applicant's Abstract): In this application, the applicants carefully addressed the important application of the proposed SPECT technique in breast cancer staging and characterization. Preliminary results from a prototype RMSSH collimator were included. Also, a new specific aim and methods to conduct an initial clinical trial of the proposed technique were added. The innovations of the proposed SPECTM technique include: (1) the use of a MSSH collimator that provides 3 to 4 times the detection efficiency within its field-of-view than a conventional collimator with the same spatial resolution, (2) the ability to acquire complete sets of projection data by simply rotating the MSSH at 2 to 3 positions on a 90 degree arc around the breast, (3) the ability for the RMSSH collimator to stay close to the breast during data acquisition for best spatial resolution, and (4) the use of fully 3D reconstruction methods that reconstruct the complete projection data sets to provide high quality, quantitatively accurate and artifact-free reconstructed images. The research design and methods include: (1) the design of special optimized MSSH collimators for the SPECTM technique, (2) the development of transmission and emission data acquisition strategies for complete projection data sets from using the rotating MSSH collimators, (3) the development of fully 3D reconstruction methods that provide quantitatively accurate reconstructed images of the breast, (4) evaluation of the 3D SPECTM images for the detection and characterization of small and low contract breast lesions, and (5) initial pilot clinical evaluation of the SPECTM technique in five patients. The proposed new SPECTM technique can be easily implemented in most nuclear medicine clinics requiring only a low cost (about $20,000) RMSSH collimator assembly. It will provide much improved capability in evaluating the extent and characterization of breast cancers for staging purposes that have been found useful in the surgical management of breast cancer.