Inorganic/Organic Nanocomposite Particles (I/O-NP); A Platform Technology for Next Generation Healthcare Applications

无机/有机纳米复合粒子(I/O-NP)是一种用途广泛的平台技术，目前正在开发用于诊断医学应用。I/O-NPs是由包裹较小的金属纳米颗粒(2-20 nm)的功能性聚合物有机纳米结构(50-200 nm)组成。平台技术的合成多功能性允许对纳米结构的组成和结构进行微调，从而为开发一类新的生物响应性功能材料提供了可能性。将磁性氧化铁纳米颗粒掺入生物响应性有机纳米结构中将产生复合材料，这些复合材料可以(A)响应生物刺激而膨胀或收缩，或(B)在生物靶标周围聚集。在任何一种情况下，所使用的铁氧化物的磁特性都会随着它们的旋转动力学和颗粒间的接近程度的变化而变化。由于生物组织不含磁性材料，I/O-NP平台技术的多功能性为广泛的医疗应用提供了一系列潜力，提供了更敏感、更具体和更定量的诊断分析，在没有背景信号的情况下实时监测和量化生物系统潜力。FLF更新的具体目标是创建世界领先的专业知识，为未来在UOL建立高级磁性医疗材料中心(AM4H)奠定基础。该中心将允许材料科学、生物学、物理学和临床科学领域的研究人员组成跨学科社区，围绕英国或欧洲目前尚不存在的尖端技术建立协同效应和研究项目。奖学金申请者马尔科·贾迪略博士通过他在诊断和治疗领域的跨学科合作和在无机和有机纳米医学研究方面的经验建立了全球声誉。这项研究计划将在利物浦大学化学系进行，关键的跨学院、跨部门和多学科的合作到位，以确保其成功的结果以及未来I/O-NP广泛平台技术的长期发展。奖学金续签的主要目标是：1.新型智能和生物响应的无机/有机纳米复合粒子的开发2。新的设备工程和临床前研究，确保知识产权的产生和产业参与3.建立多学科研究战略，培育网络，为创建医疗保健中心先进磁性材料(AM4H)奠定基础4.面向多种全球医疗保健需求的广泛I/O-NP平台技术扩展

Inorganic/Organic Nanocomposite Particles (I/O-NP) are a highly versatile platform technology, currently being developed for use in diagnostic medical applications. I/O-NPs are composed of functional polymeric organic nanoscale structures (50-200 nm) in which smaller metallic nanoparticles (2-20 nm) are encapsulated. The synthetic versatility of the platform technology allows for fine tuning of the composition and architectures of the nanoscale structures, thus offering the potential for a new class of biologically responsive, functional materials to be developed.The incorporation of magnetic iron oxide nanoparticles within biologically responsive organic nanostructures would give rise to composite materials that could (a) swell or contract in response to biological stimuli or (b) accumulate around a biological target. In either case, the magnetic characteristics of the iron oxides employed would be varied as a result of changes in their rotation dynamics and interparticle proximity. Such magnetic property variation could be exploited to design detection systems, capable of detecting minute quantities of biological stimulus.As biological tissue contains no magnetic material, the versatility of the I/O-NP platform technology offers a range of potential for wide healthcare applications, providing more sensitive, specific, and quantitative diagnostic analysis, with real-time monitoring and quantification in biological systems potential with no background signal.The specific aims of this FLF renewal are towards the creation of world-leading expertise, building towards the future establishment of the Advanced Magnetic Materials for Healthcare Hub (AM4H) at UoL. The Hub will allow for a cross-disciplinary community of researchers in fields of Materials Science, Biology, Physics and Clinical Sciences to build synergies and research projects around cutting-edge technologies that are currently not present in the UK or Europe.The fellowship applicant, Dr Marco Giardiello, has built a global reputation through his cross-disciplinary collaborations and experience of inorganic and organic nanomedicine research in both diagnostic and therapeutic areas. The research programme is to be carried out at the University of Liverpool's Department of Chemistry, with critical cross-faculty, cross-sector and multi-disciplinary collaboration in place to ensure its successful outcomes as well as long-term future I/O-NP wide platform technology development.The fellowship renewal's key aims are:1. Novel smart and biologically responsive Inorganic/Organic Nanocomposite Particle development2. Novel device engineering and pre-clinical investigation, ensuring IP generation and industrial engagement3. Establishment of multidisciplinary research strategies, fostering networks to set the foundation towards the creation of the Advanced Magnetic Materials for Healthcare Hub (AM4H)4. Wide I/O-NP platform technology expansion towards multiple global healthcare needs