Inorganic/Organic Nanocomposite Particles (I/O-NP); A Platform Technology for Next Generation Healthcare Applications

无机/有机纳米复合粒子（I/O-NP）；

• 批准号: MR/T021306/1
• 负责人: Marco Giardiello
• 金额: $ 148万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT021306%2F1
• 关键词: Inorganic; Organic; Nanocomposite; Particles; NP

In order to achieve the next generation potential nanomedicine has to offer, next generation nanomaterials must be developed. Inorganic/organic nanocomposite particles are composed of polymeric, organic nanoscale structures (50-200 nm) in which smaller metallic nanoparticles (2-20 nm) are encapsulated. Both the organic and inorganic components can be varied, giving rise to a platform technology with great composition potential. The use of inorganic/organic nanocomposites is in its infancy, but they offer a range of potential healthcare applications, from enhancement of radiotherapy for cancer treatment to providing more sensitive, specific and quantitative diagnostic analysis than current established techniques, with real-time monitoring and quantification in biological systems potential. Such materials may aid cardiovascular imaging, oncology and cell tracking but extension to infectious disease diagnostics and advanced radiotherapy would be world-leading. Inorganic/organic nanocomposite particles will offer new direction for nanomedicine research, providing the foundation for new research fields to emerge through the creation of a novel platform technology. Investigation into nanocomposites will open significant avenues for research innovation in terms of both nanocomposite material development and device development. Uniquely, the highly novel platform could be further adopted to incorporate responsive functionality, amplified disease targeting as well as the incorporation of multiple component types, thus creating multifunctional composite materials for combinational diagnostics and therapy. The platform technology, therefore, is highly adaptable allowing for a range of applications in both diagnostic and therapeutic areas, each with significant avenues to innovative material design and device development. The specific aim of this fellowship is to enable the creation of world-leading expertise within the UK, able to pioneer new science and establish impact from its application towards real-world healthcare needs. Next generation nanomaterials will give rise to new technologies which would offer considerable benefits for healthcare diagnosis and for treatment. The nanomaterial development strategy is truly multidisciplinary and thus, through this fellowship, multidisciplinary team development will be established to provide collaborative approaches aimed at the translation of research findings to clinical use. Through this strategy, novel areas of healthcare research will be established in the UK with truly global importance. In the long-term, the impact of establishing a platform technology will provide a springboard from which the applicant will develop commercial and policy influence, enabling him to become a significant global leader of innovative multidisciplinary research.The fellowship applicant, Dr Marco Giardiello, has experience of inorganic and organic nanomedicine research in both diagnostic and therapeutic areas, having established several research collaborations in both academia and industry. He has been a key lead in the identification and manufacturing processes towards clinical trial development of nanomedicines, as well as being integral in developing platform technologies through to commercial outputs having co-founded a start-up company. The research is to be carried out at the University of Liverpool's Department of Chemistry with critical cross-faculty, cross-sector and multi-disciplinary collaboration.The fellowship proposal's key aims are:1. Novel inorganic/organic nanocomposite particle development2. Multidisciplinary research team building 3. Novel nanomedicine applications creating new IP and industrial regulatory engagement4. The application of new technologies towards multiple global healthcare needs

为了实现下一代纳米医学所提供的潜力，必须开发下一代纳米材料。无机/有机纳米复合粒子由聚合物、有机纳米级结构（50-200纳米）组成，其中包裹着较小的金属纳米粒子（2-20纳米）。有机和无机成分都可以变化，从而产生具有巨大组合潜力的平台技术。无机/有机纳米复合材料的使用尚处于起步阶段，但它们提供了一系列潜在的医疗保健应用，从增强癌症放疗治疗到提供比现有技术更敏感、特异性和定量的诊断分析，在生物系统中具有实时监测和定量的潜力。这些材料可能有助于心血管成像、肿瘤学和细胞跟踪，但将其扩展到传染病诊断和高级放射治疗将是世界领先的。无机/有机纳米复合粒子将为纳米医学研究提供新的方向，通过创建新的平台技术，为新的研究领域的出现提供基础。对纳米复合材料的研究将为纳米复合材料的发展和器件的发展开辟重要的研究创新途径。独特的是，这种高度新颖的平台可以进一步被采用，以结合反应功能、放大疾病靶向以及多种成分类型的结合，从而创建多功能复合材料，用于联合诊断和治疗。因此，该平台技术具有高度适应性，可用于诊断和治疗领域的一系列应用，每种应用都具有创新材料设计和设备开发的重要途径。该奖学金的具体目标是在英国创造世界领先的专业知识，能够开拓新科学，并从其应用到现实世界的医疗保健需求中建立影响。下一代纳米材料将产生新技术，为医疗诊断和治疗提供可观的好处。纳米材料的发展战略是真正的多学科，因此，通过该奖学金，将建立多学科团队的发展，以提供旨在将研究成果转化为临床应用的合作方法。通过这一战略，医疗保健研究的新领域将建立在英国与真正的全球重要性。从长远来看，建立平台技术的影响将为申请人提供一个跳板，使他能够发展商业和政策影响力，使他成为创新多学科研究的重要全球领导者。奖学金申请人Marco Giardiello博士在诊断和治疗领域具有无机和有机纳米医学研究经验，并在学术界和工业界建立了多项研究合作。他一直是纳米药物临床试验开发的鉴定和制造过程的关键领导者，以及在开发平台技术到商业产出方面不可或缺的一部分，并与他人共同创立了一家初创公司。这项研究将在利物浦大学化学系进行，跨学院、跨部门和多学科的合作至关重要。奖学金提案的主要目标是：1。新型无机/有机纳米复合颗粒的研制多学科研究团队建设新型纳米医学应用创造新的知识产权和工业监管参与。将新技术应用于多种全球医疗保健需求

项目成果

Aqueous (co)polymer stabilisers for size-controlled 2-5 nm gold nanoparticle synthesis with tuneable catalytic activity

用于尺寸控制的 2-5 nm 金纳米粒子合成的水性（共）聚合物稳定剂，具有可调的催化活性

• DOI: 10.1039/d2nj03257k
• 发表时间: 2022
• 期刊: New Journal of Chemistry
• 影响因子: 3.3
• 作者: Traynor D

Controllable and tuneable growth of NaYbF 4 :Tm(0.5%)Fe(5%)@Na(Yb/Y)F 4 -core@shell structures and the effect of their geometry on upconversion luminescence

可控%20and%20可调%20增长%20of%20NaYbF%204%20:Tm(0.5%)Fe(5%)@Na(Yb/Y)F%204%20-核@壳%20结构%20and%20%20效果

• DOI: 10.1039/d3tc01215h
• 发表时间: 2023
• 期刊: Journal of Materials Chemistry C
• 影响因子: 6.4
• 作者: Ureña-Horno E