MEETINGS ON MODELING HUMAN CANCER IN MICE

在美国，结直肠癌是癌症死亡的第二大原因。1995年，大约有16万例新的结直肠癌病例，其中6万人死于这种疾病。在了解这种疾病的病因和改进治疗方面取得进展的要求之一是开发新的动物模型，在这种模型中可以研究正常的组织生物学和所有阶段的癌症发生。为癌症研究准备新的小鼠模型的工具已经到位；需要的是基础和临床研究人员之间关于人类肿瘤的分子生物学、它们的启动和进展与生物相关性的对话，以及实验室小鼠的建模。为此，杰克逊实验室建立了一系列关于研究人类癌症的小鼠模型的年度会议和配套研讨会，总的目标是讨论临床前小鼠模型的开发和验证及其在转化性癌症研究中的应用。本系列旨在支持NCI于1998年7月29日发布的RFA CA-98-013《人类癌症联盟(MMHCC)小鼠模型》。第一次会议于1999年10月举行，重点是乳腺癌的发生，具体目标是：1)评估目前发展小鼠乳腺癌模型的方法；2)它们在开发预防或以其他方式治疗人类乳腺癌的新治疗方法方面的潜在应用。其中第二次会议将于2000年10月26日至29日在杰克逊实验室举行，紧接着将举行题为“小鼠人类癌症建模技术”的配套研讨会，重点是结直肠癌。来自世界各地的积极研究人员和学生将有机会在肠道上皮及其肿瘤的生物学分析方面分享想法，建立新的合作关系，讨论当前的进展并规划未来的方向。这一系列会议和其他会议的记录将在万维网上公布。

Colorectal cancer is the second leading cause of cancer deaths in the United States. In 1995, there were about 160,000 new cases of colorectal cancers with 60,000 deaths resulting from the disease. One of the requirements for progress in understanding the etiology and improving the treatment of this disease is the development of new animal models in which normal tissue biology and all stages of carcinogenesis can be investigated. The tools are in place to prepare new mouse models for cancer research; what is needed is a dialog between basic and clinical researchers about the molecular biology of human tumors, their initiation and progression with respect to biological correlates and modeling in the laboratory mouse. To this end, The Jackson Laboratory has established a series of annual meetings and companion workshops on mouse models for studying human cancer with the overall goal of discussing the development and validation of preclinical mouse models and their use in translational cancer research. This series is designed to support the "Mouse Models of Human Cancer Consortium" (MMHCC) RFA CA-98-013 released by NCI on July 29, 1998. The first meeting, held in October of 1999, focused on mammary carcinogenesis with the specific objective of: 1) evaluating current approaches to the development of mouse models of mammary cancer and 2) their potential application to the development of novel therapeutic approaches to preventing or otherwise treating breast cancer in humans. The second of these meetings will be held at The Jackson Laboratory on October 26-29, 2000 immediately following a companion workshop entitled "Techniques for Modeling Human Cancer in Mice" and will focus on colorectal cancer. Active investigators and students from around the world will have an opportunity to share ideas, establish new collaborations, discuss current progress and chart future directions in the biological analysis of the intestinal epithelium and its neoplasms. Proceedings from this and other meetings in the series will be made available on the World Wide Web.