GORDON RESEARCH CONFERENCE ON LYSOSOMES

描述(取自应用程序) 请拨资金以支持#年的国内旅费和会议费。 在将于6月25日至6月30日举行的第19届溶酶体戈登会议上，美国的演讲者， 2000年，在密歇根州安多弗的普罗科特学院。这次会议提供了一个独特的 有机会进行正式的口头和海报演示，以及非正式的 旨在促进对膜相关主题的研究的讨论 正常和病理性内体-溶酶体系统的转运 条件。这一领域的快速进展将使关于 内吞作用和溶酶体靶向的分子机制，以及 内小体和溶酶体在突触传递等过程中的作用 细菌致病机制，寄生虫与宿主的相互作用，抗原提呈， 调节胰岛素反应，控制细胞增殖。 会议将包括：1。内吞机制的结构。2. 内吞作用的机制。3.内吞途径中的运输和分选。4. 内体-溶酶体系统中的囊泡萌发和融合。5.蛋白质 在TGN分拣。6.溶酶体功能和动力学。7.酵母液泡。8. 溶酶体的生物发生和功能障碍。这些会议将提供 与各种疾病直接相关的最新信息 主题，包括神经疾病，细菌和寄生虫病， 糖尿病、免疫性疾病、疫苗开发、溶酶体储存 疾病、色素沉着和凝血障碍。因为这种关联性 对于转化型临床研究，这次会议定期有以下人员参加 对开发新的治疗途径感兴趣的医学研究人员。 演讲者将包括这一领域的许多公认的世界领导人以及 更年轻的调查员。三分之一的演讲者和会议主席是女性， 密切反映了这一研究领域的人口统计学特征。的目标是 会议的目的是提供一个自由交流新成果的论坛，以便 在科学家之间产生新的想法和合作，来自各种不同的 背景。

DESCRIPTION (taken from the application) Funds are requested to support domestic travel and conference fees for U.S.-based speakers at the 19th Lysosome Gordon Conference to be held June 25 to June 30, 2000 at the Proctor Academy, Andover, NH. The conference provides a unique opportunity for formal oral and poster presentations, as well as informal discussions aimed at stimulating research on topics related to membrane trafficking in the endosomal-lysosomal system in normal and pathological conditions. Rapid progress in this field will enable discussions on the molecular mechanisms of endocytosis and lysosomal targeting, as well as the role of endosomes and lysosomes in processes such as synaptic transmission, bacterial pathogenesis, parasite-host interactions, antigen presentation, regulation of insulin-responsiveness, control of cellular proliferation. Sessions will include: 1. The structure of the endocytic machinery. 2. Mechanisms of endocytosis. 3. Transport and sorting in the endocytic pathway. 4 Vesicle budding and fusion in the endosomal-lysosomal system. 5. Protein sorting at the TGN. 6. Lysosome function and dynamics. 7. The yeast vacuole. 8. Disorders of lysosome biogenesis and function. These sessions will provide up-to-date information of direct relevance to a variety of disease-related topics, including neurological disorders, bacterial and parasitic diseases, diabetes, immunological diseases, vaccine development, lysosomal storage disorders, pigmentation and blood clotting disorders. Because of this relevance to translational clinical research, this meeting is regularly attended by medical researchers interested in the development of new therapeutic avenues. Speakers will include many recognized world leaders in this field, as well as younger investigators. One third of the speakers and session chairs are female, reflecting closely the demography of this area of research. The goal of the Conference is to provide a forum for the free exchange of new findings so as to generate new ideas and collaborations among scientists from a variety of backgrounds.