BASIC AND CLINICAL BIOLOGY OF CUTANEOUS T CELL LYMPHOMA

描述(申请人的描述)纽约科学院是 主办题为：基础和临床相关生物学的会议 2000年春末皮肤T细胞淋巴瘤。首席调查员和 主席是理查德·L·埃德森，医学博士，教授兼系主任 耶鲁大学医学院皮肤科。联席主席是文森特 医学博士，医学教授兼综合癌症中心主任 耶鲁大学医学院研究中心。 这次会议的目的是扩大两国之间的科学交流。 领先的免疫学家、血液肿瘤学家、实验病理学家和 皮肤科医生对皮肤T细胞淋巴瘤的研究 将这种疾病更多地纳入癌症主流，并突出 在理解方面取得了重大进展，最近几年 好几年了。 皮肤T细胞淋巴瘤(CTCL)受到科学界的广泛关注 和临床社区，因为它是一种相对常见和危险的 恶性肿瘤，这是一种广泛的 免疫疗法。然而，自从埃德尔森博士的团队首次发现 并主持了一次关于这一主题的NIH临床工作人员会议， 后来发表在《内科医学年鉴》上的文章一直很少 的综合会议有效地将生物学的知识 CTCL在更广泛的背景下研究其他淋巴瘤。这导致了一种 不幸的是，专业知识被分割开来，甚至被孤立 紊乱：皮肤科医生中的一大群，只有少量的 肿瘤学家和病理学家都致力于这一课题。我们希望能催化 免疫学家之间就这一重要主题进行直接沟通，世卫组织 研究这种成人最常见的T淋巴细胞恶性肿瘤， 皮肤科医生，他们经常照顾重病患者，并进行研究 肿瘤学家和实验病理学家，他们的专业知识可以帮助 更快地掌握与临床相关的CTCL生物学知识。 会议记录将以卷的形式发表在《纽约纪事报》上 这本书是美国科学院出版的，将在国际上发行。

DESCRIPTION (Applicant's Description) The New York Academy of Sciences is sponsoring a conference entitled: Basic and Clinically Relevant Biology of Cutaneous T Cell Lymphoma in late Spring, 2000. The principal investigator and chair is Richard L. Edelson, M.D., Professor and Chairman Department of Dermatology, Yale University School of Medicine. The cochair is Vincent DeVita, M.D., Professor of Medicine and Director of the Comprehensive Cancer Center, Yale University School of Medicine. The purpose of this conference is to broaden the scientific exchanges between leading immunologists, hemato-oncologists, experimental pathologists and investigative dermatologists on the subject of Cutaneous T Cell Lymphoma, to bring this disease more into the cancer mainstream and to highlight the significant advances in its understanding that have been made in recent years. Cutaneous T cell lymphoma (CTCL) receives much attention from the scientific and clinical communities, since it is a relatively common and dangerous malignancy, which serves as a testing ground for a wide range of immunotherapies. However, since Dr. Edelson's team first identified the disease in 1975 and conducted an NIH Clinical Staff Conference on the subject, later published in the Annals of Internal Medicine, there has been a paucity of comprehensive conferences effectively placing knowledge of the biology of CTCL in the broader context of research in other lymphomas. This has led to an unfortunate compartmentalization, and even isolation, of expertise in the disorder: a large subset of dermatologists, with only a sprinkling of oncologists and pathologists, have worked on the subject. We hope to catalyze direct communication on the important subject between immunologists, who investigate this most common adult malignancy of T lymphocytes, dermatologists, who care for the often seriously ill patients, and research oncologists and experimental pathologists, whose expertise could help move knowledge of clinically relevant CTCL biology forward, even faster. The proceedings will be published as a volume in the Annals of the New York Academy of Sciences and will be distributed internationally.