6TH RESEARCH CONFERENCE ON THROMBOLYSIS

本申请是对将于2000年2月6日至11日在加州文图拉的文图拉假日酒店举行的第六届戈登溶栓研究会议的部分支持。该国际会议自1990年以来每两年举行一次，深入讨论溶栓领域最令人兴奋的最新进展以及纤溶蛋白在血管生成，肿瘤进展和神经生物学中的作用。 将涵盖基础科学和临床蛋白质开发的新进展。重点将放在新的概念，从蛋白质结构，在纤维蛋白溶解系统和整合素功能，神经元功能，动脉粥样硬化，血管生成和基质生物学之间的新出现的关系。此外，新开发的中风治疗的临床药物将进行讨论。计划举办九次会议，内容包括：1.丝氨酸蛋白酶抑制剂结构与功能研究进展2。纤维蛋白溶解和基质生物学3.纤溶受体：在细胞功能中的作用4。血管生成和血管抑素5.纤溶系统在肿瘤进展中的作用6.金属蛋白酶、动脉粥样硬化和纤溶酶系统7.最新突破的主题和选定的海报介绍8.神经生物学和纤溶蛋白9.新的治疗性蛋白质在治疗中风这次会议将是一个主要的工具，为新的知识整合在溶栓/纤溶研究领域。其目标是让每个参与者都能全面了解这个迅速扩大的领域的基本生物学过程和临床进展。 会议将包括妇女和少数民族作为会议领导人和发言人。将尽一切努力让博士后研究员和研究生参加讨论、下午的海报会议，并在适当的时候担任演讲者。作为会议主席，斯特里克兰博士将尽一切努力在这次会议上介绍新的和年轻的研究人员，并为他们提供在讨论中发挥领导作用的机会。

This application is for partial support of the sixth Gordon Research Conference on Thrombolysis to be held at the Ventura Holiday Inn in Ventura California on February 6-11, 2000. This international conference has been held every two years since 1990, and provides in-depth discussions of the most exciting and recent developments in the field of thrombolysis and the role of fibrinolytic proteins in angiogenesis, tumor progression, and in neuronal biology. New advances in both basic science and in the development of clinical proteins will be covered. Emphasis will be placed on novel concepts learned from protein structure, in newly emerging relationships between the fibrinolytic system and integrin function, neuronal function, atherosclerosis, angiogenesis, and matrix biology. Further, newly developed clinical agents for stroke therapy will be discussed. Nine sessions are planned and will cover: 1. Advances in serpin structure and function 2. Fibrinolysis and matrix biology 3. Fibrinolytic receptors: role in cellular function 4. Angiogenesis and angiostatin 5. Role of the fibrinolytic system in tumor progression 6. Metalloproteinases, atherosclerosis, and the plasmin system 7. Late breaking topics and presentation of selected posters 8. Neurobiology and fibrinolytic proteins 9. New therapeutic proteins in the treatment of stroke This conference will be a major vehicle for the integration of new knowledge in the field of thrombolysis/fibrinolysis research. The goal is for each participant to acquire a comprehensive state-of-the-art understanding of basic biologic processes and clinical advances in this rapidly enlarging field. The conference will include women and minorities as session leaders and speakers. Every effort will be made to include post- doctoral fellows and graduate students in discussions, afternoon poster sessions, and as speakers where appropriate. As Conference Chair, Dr. Strickland will make every effort to profile new and young investigators in this conference, and to provide them with the opportunity to take a leadership role in discussions