10TH INTERNATIONAL P53 WORKSHOP

国际p53研讨会一直吸引着p53领域的科学家进行互动，讨论他们的最新科学发现并计划合作。 该系列现已在p53科学界及其他领域得到广泛认可，该领域的所有专家都参加了该系列。 p53肿瘤抑制基因是研讨会的焦点，它比任何其他已知基因更常参与人类癌症。 与皮肤癌和结肠癌的关系尤其密切，前者紫外线照射导致p53突变，后者化学致癌物诱导p53突变。 值得注意的是，每种类型的环境致癌物都会引起p53基因的特定遗传损伤，这使得科学家能够从突变类型中确定罪魁祸首。 在细胞水平，p53参与细胞周期停滞、衰老和凋亡。 第10届国际p53研讨会是由位于加州弗朗西斯科的加州大学组织的。 讲习班将于2000年4月5日至8日在美国加州蒙特雷举行。 组委会按字母顺序由以下人员组成：Thanos Halazonetis博士（美国Wistar研究所）、Curtis Harris博士（美国NCI）、大卫莱恩博士（美国U.邓迪，英国），阿诺德莱文博士（洛克菲勒大学，美国），Frank McCormick博士（UCSF癌症中心，美国），Moshe Oren博士（以色列魏茨曼研究所），Carol Prives博士（哥伦比亚大学，USA）、Varda Rotter博士（Weizmann Institute，以色列）、Thierry Soussi博士（Genotoxilogie et Modulation De I'Expression Genique，法国）、Thea Tlsty博士（Ph.D.）主席（U。of加州，美国弗朗西斯科），Karen Vousden博士（NCI，美国）和Geoffrey Wahl博士（Salk Institute，美国）。 到目前为止，组委会正在筹集大量资金，以支付受邀演讲者的费用。然而，第二个重要目标是为美国研究生和博士后，包括妇女，少数民族和残疾人提供旅行奖学金。 该提案要求NIH为此类奖学金提供支持。

The International p53 Workshops have consistently attracted scientists in the p53 field to interact, discuss their latest scientific findings and plan collaborations. The series is now well-established in the p53 scientific community and beyond, and it is attended by all experts in the field. The p53 tumor suppressor, which is the focus of the Workshop, is involved in human cancer more often than any other gene known. Particularly strong connections are with skin cancer, where UV-irradiation leads to mutations in p53, and with colon carcinoma, where chemical carcinogens induce mutations in p53. Remarkably, each type of environmental carcinogen causes a specific genetic lesion in the p53 gene, allowing scientists to identify the culprit from the type of mutation. At a cellular level, p53 is involved in cell cycle arrest, senescence and apoptosis. The 10th International p53 Workshop is organized by the University of California at San Francisco, California. The Workshop will be held in Monterey, California, United States between April 5th-8th, 2000. The organizing committee consists, in alphabetical order, of: Dr. Thanos Halazonetis, (Wistar Institute, USA), Dr. Curtis Harris (NCI, USA), Dr. David Lane (U. Dundee, UK), Dr. Arnold Levine (Rockefellar U., USA), Dr. Frank McCormick (UCSF Cancer Center, USA), Dr. Moshe Oren (Weizmann Institute, Israel), Dr. Carol Prives (Columbia U., USA), Dr. Varda Rotter (Weizmann Institute, Israel), Dr. Thierry Soussi (Genotoxilogie et Modulation De I'Expression Genique, France), Dr. Thea Tlsty, Ph.D., Chair (U. of California, San Francisco, USA), Dr. Karen Vousden (NCI, USA) and Dr. Geoffrey Wahl (Salk Institute, USA). So far the organizing committee is raising significant funds to cover the expenses of invited speakers. However, a second important goal is to secure travel fellowships for U.S. graduate students and post-doss, including women, minorities and persons with disabilities. This proposal requests support from the NIH for such fellowships.