CEREBRAL BLOOD FLOW AND DEVELOPMENT METABOLISM

在胎儿和新生儿时期发生的脑血流和代谢紊乱是儿童和成人永久性脑损伤和脑功能障碍的主要原因。围产期脑损伤的动物模型已经有二十多年的历史，它有助于阐明所涉及的生理和生化过程。最近，细胞和分子生物学技术已被应用于正常和异常脑发育的研究。因此，拟议会议的总体目标是汇集国际知名的临床和基础科学家，参与有关发育中的动物和人类的脑血流和代谢的研究。会议将主要集中在正常和异常的大脑发育和功能的机制，并将根据我们以前在宾夕法尼亚州好时成功举行的会议，在1997年程式化。主要内容包括：1）基本机制; 2）缺氧缺血; 3）其他应激; 4）当前研究技术。每个主题将专门举办一个或多个平台和海报会议，预计所有与会者都会出席并积极参与。几位受邀演讲者已经承诺参加会议，等待NIH的财政支持。会议在宾夕法尼亚州好时举行，将提供一个轻松的乡村氛围，所有主要城市都可以轻松到达。预计会议将在非正式的环境中汇集一批杰出的临床和基础科学家，以促进最大限度的互动和传播新的和令人兴奋的研究。

Disturbances in cerebral blood flow and metabolism occurring during the fetal and neonatal periods are major contributors to permanent brain damage and cerebral dysfunction in children and adults. Animal models of perinatal brain damage have been available for more than two decades, which have aided in the elucidation of the physiologic and biochemical processes involved. More recently, cellular and molecular biological techniques have been applied to the study of normal and abnormal cerebral development. Accordingly, the overall objective of the proposed meeting is to bring together internationally known clinical and basic scientists involved in research pertaining to cerebral blood flow and metabolism in developing animals and humans. The conference will focus primarily on mechanisms of normal and abnormal cerebral development and function and will be stylized according to our previously successful meeting held in Hershey, Pennsylvania, in 1997. Four major themes will be covered: l) Basic mechanisms; 2) Hypoxia-Ischemia; 3) Other stresses; and 4) Current research techniques. One or more platform and poster sessions will be devoted to each theme with the anticipation that all attendees will present and also engage in active participation. Several invited speakers are already committed to the conference, pending NIH financial support. The setting of the meeting in Hershey, Pennsylvania, will provide a relaxing, rural atmosphere which is still readily accessible to all major cities. It is anticipated that the conference will bring together an outstanding group of clinical and basic scientists in an informal environment to promote maximal interaction and the dissemination of new and exciting research.