CONSULTATION IN BIOSTATISTICAL METHODOLOGY AND CANCER CONTROL

这个项目的目的是提供独立的咨询 NCI内与生物统计学相关问题的研究人员 方法学和癌症控制。目前的项目包括： -与癌症预防研究科合作， 美国退休人员协会(AARP)观察性队列研究 已经进入了第三个年头。在过去的一年里，美国退休人员协会的一个队列 创建成员是为了调查当前成员之间的关系 饮食摄入量和他们未来乳腺癌的发病率， 结肠/直肠和前列腺的内部校准研究 包括约2,000名全部队列成员；以及 24小时饮食召回和第二次食物频率问卷(FFQ) 是为校准研究的对象获得的。三、分析了 校准研究已经开始，这将使我们能够评估FFQ 测量误差并对此进行主要研究结果的修正 错误。 -与癌症预防研究科合作，我们 已完成的1)膳食叶酸摄入量与结直肠癌的研究项目 2)膳食脂肪和纤维摄入对雄激素和 男性体内的雌激素水平。 -与癌症预防研究科和 应用研究部，一个新开发的FFQ正在评估中；完毕 600名参与者参加了一项研究，该研究使用了每天的 要评估样本的食物频率准确性的选定食物 调查问卷项目。 -与预防和控制校外处合作， 部分提供了对5A的分析和评估的咨询 日间计划--NCI增加水果和蔬菜的活动 消费。 -与应用研究科和环境保护署合作 DCEG流行病学分会，硒状况与疾病的关系 宫颈癌正在接受调查。

The purpose of this project is to provide independent consultation to researchers within the NCI on problems related to biostatistical methodology and cancer control. Current projects include: - in collaboration with the Cancer Prevention Studies Branch, the American Association of Retired Persons (AARP) Observational Cohort Study has entered its third year. During the past year, a cohort of AARP members was created to investigate the relationship between their current dietary intake and their future incidence of cancer of the breast, colon/rectum, and prostate the internal calibration study has been constructed that includes about 2,000 members of the full cohort; and the 24-hour diet recalls and the second food frequency questionnaire (FFQ) were obtained for the subjects of the calibration study. Analysis of the calibration study has begun, which will allow us to evaluate the FFQ measurement errors and to correct the results of the main study for this error. - in collaboration with the Cancer Prevention Studies Branch, we completed research projects on 1) dietary folate intake and colorectal cancer and 2) the effects of dietary fat and fiber intake on androgen and estrogen levels in men. - in collaboration with the Cancer Prevention Studies Branch and the Applied Research Branch, a newly developed FFQ is being evaluated; over 600 participants were enrolled in a study using a daily checklist of selected foods to evaluate the food frequency accuracies of a sample of questionnaire items. - in collaboration with the Prevention and Control Extramural Branch, the Section provides consultation on the analysis and evaluation of the 5 A Day Program -- NCI's campaign to increase fruit and vegetable consumption. - in collaboration with the Applied Research Branch and the Environmental Epidemiology Branch, DCEG, the relationship between selenium status and cervical cancer is being investigated.