DEVELOPMENT OF A MONKEY MODEL FOR TESTING OF ANTIVIRAL AGENTS AGAINST HIV1

黑猩猩可以感染HIV-1;然而，由于这个物种是 濒危动物的维护成本非常高， 限于实验研究。 因此，我们寻求一种更好的模式。 我们 在猪尾猕猴中进行HIV- 1感染的研究。 最初我们 用LAV/LAI（HIV-1和2的实验室毒株）感染2只猴子 携带HIV-1病毒的猴子 分析 接种LAV的猴子表明两只猴子都被感染， 长期含有病毒序列。 目前正在进行研究， 宿主因素和病毒决定因素，控制建立 感染、病毒产生水平和最终进展 疾病。 这些研究的结果有望使 猪尾猴成为人类艾滋病的有用动物模型。 在 此外，还正在对猴子中的HIV-1主要分离株进行分析， 贯彻 以来 后者是自然的代表 在人类感染中，将使用初级分离株的动物模型， 对有效的HIV-1的开发和安全性测试有价值 疫苗和治疗剂。 目前人类艾滋病流行。 主要努力和资源 一直致力于开发疫苗和治疗方法 对抗HIV-1和艾滋病。 非人类灵长类动物模型的可用性 对于评估疫苗的安全性和有效性至关重要 以及为人类艾滋病干预和治疗开发的疗法。 此外，HIV-1感染的动物模型将能够更好地 了解病毒感染的机制， 疾病 此信息将为提交的产品提供更好的审查 FDA进行评估。

Chimpanzees can be infected with HIV-1; however, since this species is endangered their maintenance cost is very high and the number of animals limited for experimental research. Thus a better model is sought. We have pursued HIV- 1 infection in pig-tailed macaques. Initially, we infected 2 monkeys with LAV/LAI, a laboratory strain of HIV-1 and 2 monkeys with a primary isolate of HIV-1. Analysis of the LAV-inoculated monkeys indicated that both monkeys were infected and contain viral sequences long-term. Current studies are underway to pursue host factors and viral determinants which control the establishment of infection, the level of virus production and the eventual progression to disease. The results from such studies will hopefully enable the pig-tailed monkeys to become a useful animal model for human AIDS. In addition, analysis of HIV-1 primary isolates in monkeys is also being carried out. Since the latter are representative of the natural infection in people, an animal model utilizing primary isolates will be valuable for the development and safety testing of effective HIV-1 vaccine(s) and therapeutic(s). There is a current epidemic of human AIDS. Major efforts and resources have been directed towards development of vaccines and therapeutics against HIV-1 and AIDS. The availability of a non-human primate model for AIDS is critical for evaluating the safety and efficacy of vaccines and therapeutics developed for human AIDS intervention and treatment. Furthermore, an animal model for HIV-1 infection will enable a better understanding of the mechanism of virus infection and development of disease. This information will provide better review of product submitted to FDA for evaluation.