CHRONIC DISEASE RISKS ASSOCIATED WITH MERCURY VAPOR EXPOSURE

工作总结：我们正在与国家航空航天局的研究人员合作 糖尿病、消化和肾脏疾病研究所与美国 牙科医生患终末期肾病风险的牙科协会 暴露在汞和一氧化二氮中。我们正在比较13.8万名美国人 1977年前在美国肾脏疾病登记处毕业的牙医 看看高度接触汞的普通牙医是否有 肾功能衰竭的发生率高于正畸医生和其他专科医生 曝光率较低的人。我们还会看看口腔外科医生和 接触一氧化二氮增加的儿科医生增加了 费率。 比约克曼博士、桑德勒博士和我正在分析来自NHANES I的数据 在一个人的牙科汞齐数量之间的关系 口腔和他们的舒张压。假设是这样的 铅、汞可能会破坏肾功能，增加患 高血压。我们还在研究一种汞齐的数量是否 人的嘴巴会增加他们精神健康不良的风险。 根据我们早先的流行病学发现，戴维斯博士和戴维斯博士。 摩根已经开始了一系列关于内分泌时间进程的实验 汞蒸气对大鼠的破坏作用。主要的问题是 这种机制是否更有可能涉及直接的卵巢毒性 或下丘脑-脑垂体轴的破坏。

Summary of Work: We are collaborating with researchers from the National Institute of Diabetes and Digestive and Kidney Diseases and the American Dental Association of the risk of end stage renal disease among dentists exposed to mercury and nitrous oxide. We are comparing 138,000 U.S. dentists who graduated before 1977 with the U.S. renal disease registry to see whether general dentists who are highly exposed to mercury have higher rates of renal failure than orthodontists and other subspecialties who have lower exposures. We will also look whether oral surgeons and pedodontists who have elevated nitrous oxide exposures have increased rates. Dr. Bjorkman, Dr. Sandler, and I are analyzing data from NHANES I to look at the relationship between the number of dental amalgams in a person's mouth and their diastolic blood pressure. The hypothesis is that like lead, mercury might disrupt renal function and increase the risk of hypertension. We are also looking at whether the number of amalgams in a person's mouth increases their risk of poor mental health. In response to our earlier epidemiologic findings, Dr. Davis and Dr. Morgan have begun a series of experiments on the time course of endocrine disruption in rats exposed to mercury vapor. The primary question is whether the mechanism is more likely to involve direct ovarian toxicity or disruption of the hypothalamic-pituitary axis.