Diabetic cardiomyopathy: defining new mechanisms of cardiomyocyte injury and loss

在1型和2型糖尿病的发展过程中，心脏被认为是一个重要的损伤器官。我们有新的证据表明，在糖尿病和糖尿病前期的心脏中，为了清除代谢燃料，心脏细胞结构会过度分解，而这种清除会导致心脏细胞死亡。我们的目标是确定保护心脏免受这种病理影响的方法，并确定治疗糖尿病心脏的新分子靶点。

The heart is recognized as an important casualty organ in the progression of diabetes – both type 1 and type 2. We have new evidence that in diabetic and pre-diabetic hearts there is excess breakdown of heart cell structure in order to scavenge metabolic fuel, and that this scavenging can lead to heart cell death. Our goal is to identify ways in which the heart may be protected against this pathology and to identify new molecular targets for treatment of diabetic hearts.