Diabetic cardiomyopathy - new molecular intervention targets and a biomarker strategy

糖尿病是一种流行病。死亡的主要原因是心脏损伤，目前还没有专门的心脏治疗方法。在这个项目中，我们研究了葡萄糖相关损伤对蛋白质的作用，这些蛋白质是调节有效心脏收缩和泵作用的关键，并寻求新的机会来测量这些蛋白质作为疾病的血液生物标志物。目的是促进对疾病机制的理解，并制定诊断糖尿病患者心脏葡萄糖损伤的策略。

Diabetes is an epidemic disease. The major cause of death is due to heart damage and no cardiac specific therapies are available. In this project we investigate the role of glucose-related damage to the proteins which are key in regulating effective heart contraction and pump action and pursue new opportunities to measure these proteins as a blood biomarker of disease. The aim is to advance understanding of disease mechanisms and develop a strategy to diagnose cardiac glucose damage in diabetes.