COGNITION IN AGING AND ALZHEIMERS DISEASE--AN FMRI STUDY

描述（改编自研究者摘要）：在许多组分中 阿尔茨海默病（AD）的认知影响，两个特定的认知 领域有特殊的临床意义：测试情节记忆（延迟 回忆和识别）对于检测AD是高度敏感的，并且 语义检索（命名和流畅性）是最好的分期疾病， 追踪它的进程 记录解剖学和生理学 在活体中这些损伤的相关性提供了对 潜在的解剖学和功能性脑损伤的分布 产生AD。 为了追求这种方法，从而扩大理解， 研究人员建议， 进行了一系列的实验超过3年有关认知测试 在这两个领域的表现，海马体积和模式， 用功能性磁共振成像测量神经激活。

DESCRIPTION (adapted from investigator's abstract): Of the many components of cognition affected in Alzheimer's disease (AD), two particular cognitive domains have special clinical relevance: tests of episodic memory (delayed recall and recognition) are highly sensitive for detecting AD, and tests of semantic retrieval (naming and fluency) are best for staging the disease and tracking its progression. Documenting the anatomical and physiological correlates of these impairments in the living subject gives insights into the distribution of the underlying anatomical and functional brain lesions that produce AD. To pursue this approach, and thereby extend understanding of brain-behavior relations in aging and AD, the investigators propose to conduct a series of experiments over 3 years relating cognitive test performance in these two domains to hippocampal volume and to patterns of neural activation measured with functional magnetic resonance imaging.