RADIATION BIOLOGY TRAINING GRANT

描述（申请人描述）：这是一份培训资助计划的竞争性更新申请，旨在培训具有辐射分子、细胞和组织效应知识的辐射生物学家。招收博士预科生6人，博士后培养6人。培训将在宾夕法尼亚大学医学院放射肿瘤系肿瘤研究部的放射生物学实验室进行。该计划将包括正式的课程，一个系列讲座和一个专为申请人培训需要而设计的期刊俱乐部，研究研讨会和会议，以及由既定研究人员监督的实验室研究项目。研究项目将集中在参与实验室目前获资助研究领域的各个方面；在研究项目方面，学员将利用现代生物学发展的技术进行辐射生物学/肿瘤学方面的机械导向研究。10名培训主任和督导所涉及的研究领域广泛涉及癌症研究，包括致癌和诱变的分子机制、分子和细胞辐射生物学、辐射化学和生物化学、DNA修复过程、癌症预防和放射肿瘤学。预计该培训计划的毕业生将继续他们在放射生物学和肿瘤学方面的研究和学术生涯。

DESCRIPTION (Applicant's Description): This is a competitive renewal of a training grant proposal for a program designed to train radiation biologists who will have knowledge of the molecular, cellular and tissue effects of radiation. Six predoctoral and 6 postdoctoral trainees are requested. Training will be offered in the radiation biology laboratories of the Division of Oncology Research, Department of Radiation Oncology at the University of Pennsylvania School of Medicine. The program will involve formal coursework, a lecture series and a journal club designed for the training needs of the applicants, research seminars and conferences, and laboratory research projects to be supervised by established investigators. The research projects will focus on various aspects of the currently funded research areas in the participating laboratories; for research projects, trainees will utilize techniques developed in modern biology to perform mechanistically-oriented studies in radiation biology/oncology. The research areas in which the 10 training directors and supervisors are involved are broadly based in cancer research, including molecular mechanisms in carcinogenesis and mutagenesis, molecular and cellular radiation biology, radiation chemistry and biochemistry, DNA repair processes, cancer prevention and radiation oncology. It is expected that graduates of the training program will continue with their research and academic careers in radiation biology and oncology.