PREHAB VS REHAB FOR REDUCING BEDREST EFFECTS WITH AGING

描述（改编自申请人的摘要）： 疾病、手术或受伤往往会给老年人带来严重的后果。 成年人，包括身体功能减退和独立性受损。 老年人可能会失去进行日常基本活动的能力， 失去了短距离行走的能力。 此外，本发明还提供了一种方法， 老年人在卧床休息一段时间后可能无法恢复功能， 导致永久性功能丧失和可能的疗养院安置。 康复已被发现是更有效的卧床休息后，比 根本没有干预，但很少有患者恢复到以前的水平， 功能 最大限度减少卧床休息期间功能丧失的新策略， 需要优化身体功能恢复的策略。 一个可能 减轻功能丧失和身体衰退的策略是提供 在一段时间的卧床休息之前， 其目的在于 这项研究的目的是检验预训练的有效性， 与传统康复相比，使用卧床休息的动物模型。 步行能力、肌肉功能和僵硬度以及骨量和 将在接受以下药物的幼龄和老龄动物中检查强度 在模拟卧床休息前进行预锻炼。 这些将被比较 在接受康复锻炼的年轻和年老动物中取得的进展 在模拟卧床休息后。 如果初步调查结果得到证实， 为适当的人类研究提供支持，并扩大 为老年人提供的保健服务，包括保健前和保健后的保健服务。 康复活动.

DESCRIPTION (Adapted from the Applicant's Abstract): Bed rest secondary to illness, surgery or injury often has serious consequences for the older adult, including diminished physical function and compromised independence. Older adults may lose the capacity to perform basic activities of daily living and lose their ability to ambulate short distances. In addition, older adults may not recover function following a period of bed rest, resulting in permanent loss of function and possible nursing home placement. Rehabilitation has been found to be more effective following bed rest than no intervention at all but rarely do patients regain former levels of function. New strategies to minimize loss of function during bed rest and strategies to optimize return of physical function are needed. One possible strategy to attenuate loss of function and physical decline is to provide pre-habilitation services prior to a period of bed rest. It is the intent of this study to examine the effectiveness of pre-habilitation exercises, compared to traditional rehabilitation, using an animal model of bed rest. Changes in walking ability, muscle function and stiffness, and bone mass and strength will be examined in young and old animals receiving pre-habilitation exercise before simulated bed rest. These will be compared to gains made in young and old animals receiving rehabilitation exercise after simulated bed rest. If preliminary findings are confirmed, it would provide support for appropriate human studies, and for expansion of habilitation services to older adults to include both pre-habilitation and rehabilitation.