SIESTA NAPS IN OLDER PEOPLE

描述(摘自申请者的摘要)：这项研究是一项新的研究 与行为干预有关的建议，即采取 午睡，这可能会减轻一些睡眠和警觉障碍 许多年长的男人和女人都有过这种经历。这项实验的主要目的是 是为了确定对于老年人(70岁以上)来说，每天提前90分钟 下午“午睡”养生法，在家中应用2周，然后 在实验室呆3天，有助于提高夜间警觉性和预防 不想要的早晚嗜睡(UEE)，可能在傍晚表现出来 午睡和/或高级睡眠相综合症(ASPS)症状。一个 将采用学科内设计，所有学科同时进行这两项工作 条件，一半的受试者先进行午睡，一半的受试者 先别睡午觉了。两人之间将有18天的时间 条件。申请者将学习健康控制和睡眠。 主诉尿失禁症状、期待干预的精神障碍患者 对患者群体最有利。以家庭为基础的措施将 包括对警觉性、睡眠(和午睡)日记的主观评分，社交 节奏度量(SRM)，以及腕部活动和光的行为测量 水平。实验室测量还将包括直肠温度， 睡眠和睡眠的多导睡眠图测量，以及单一的MSLT和清醒的脑电 晚间的困倦程度。对于患者(10m，10f)和对照组 (10m，10f)组，申请者将检验午睡的假设 午睡养生法，在家休息14天，在家休息3天 实验室，将有以下效果：1)推迟自己选择的就寝时间 和/或消除夜间小睡，2)提高体力训练的夜间表现 灵巧、连续反应、反应抑制和视觉单调 警戒任务，3)提高夜间主观警觉性(自评) 减少客观夜间嗜睡(MSLT试验，清醒脑电 分析)，4)改变光曝光模式和5)增加 生活方式规律性的水平。这种干预源于Borbely的 原创人类昼夜节律系统的“S进程/C进程”模型，以及 实验室睡眠和昼夜节律措施将另外用于 研究模型的机制，并评估以下任何后果 午睡取决于昼夜节律、节律和夜间睡眠。结果 将揭示老年人的潜在好处(和成本) 生活方式包括午睡的人，以及 确定这些指标在健康老年人和那些抱怨疾病的老年人之间有何不同 与不想要的傍晚嗜睡有关的症状。

DESCRIPTION (Adapted from applicant's abstract): This study is a new proposal concerned with a behavioral intervention, that of taking an afternoon nap, which might lessen some of the sleep and alertness disorders experienced by many older men and women. The major aim of this experiment is to determine whether for older people (70y+), a daily 90-minute early afternoon "siesta nap" regimen, applied for 2 weeks in the home followed by 3 days in the laboratory, will help promote evening alertness and prevent Unwanted Early Evening Sleepiness (UEES) which may be manifest as evening napping and/or Advanced Sleep Phase Syndrome (ASPS) symptoms. A within-subject design will be employed with all subjects doing both conditions, half of the subjects doing the 'nap' condition first, half the 'no-nap' condition first. Eighteen days will intervene between the two conditions. The applicants will study both healthy controls and sleep disorders patients who complain of UEES symptoms, expecting the intervention to be most beneficial for the patient group. Home-based measures will include subjective ratings of alertness, sleep (and nap) diaries, the Social Rhythm Metric (SRM), and Actillume measures of wrist activity and light level. Laboratory measures will additionally include rectal temperature, polysomnographic measures of naps and sleeps, and single MSLT and waking EEG evening measures of sleepiness. For both patient (10m, 10f) and control (10m, 10f) groups, the applicants will test the hypothesis that the siesta nap regimen, imposed for 14 days at home and for three days in the laboratory, will have the effect of: 1) delaying the self selected bedtime and/or eliminating evening naps, 2) improving evening performance at manual dexterity, serial response, response inhibition and monotonous visual vigilance tasks, 3) increasing evening subjective alertness (self- rated) and decreasing objective evening sleepiness (MSLT trial, waking EEG analysis), 4) changing the pattern of light exposure and 5) increasing the level of lifestyle regularity. The intervention is derived from Borbely's original "Process S/Process C" model of the human circadian system, and laboratory sleep and circadian measures will be used additionally to investigate the mechanisms of the model, and to evaluate any consequences of the siesta naps on circadian rhythm timing and nocturnal sleep. Results from the experiment will reveal the potential benefits (and costs) to older people of a lifestyle that incorporates an early afternoon nap, and determine how these vary between healthy seniors and those complaining of symptoms related to unwanted early evening sleepiness.