HOST LYMPHOCYTE RESISTANCE TO HIV1

描述(改编自摘要)：这是一个将继续进行的项目 宿主对HIV-1的遗传抗性研究。该项目是从 早期的研究表明，随机个体的CD4淋巴细胞 对某些类型的T细胞具有不同的敏感性- 营养丰富的艾滋病毒。这似乎是由基因决定的，因为 对特定供体的敏感或抗性表型是一致的 一种特定的艾滋病毒毒株，因为它在一个家庭中分离。两年 进一步证明了这种不同的敏感性 根据更多的家庭隔离研究判断是由基因决定的， 它似乎是一种独特的阻力，是一种进入后的阻力 限制病毒，不是由受体介导的。其他研究 在此期间，也显示出两个“暂时性”艾滋病毒病例 成人的感染与这种宿主淋巴细胞耐药有关。 已经建立了两个新的高危人群队列，它们是 目前正在研究确定暂时性感染的频率 如果宿主对T细胞营养型HIV毒株的遗传抵抗力正在发挥作用 在暂时性感染和对感染的抵抗力方面都有作用。这个 该项目的具体目标：(1)绘制这一病毒的决定因素图 寄主抗性；(2)在人类基因组中定位抗性基因； 以及(3)进一步证明这些基因是否在 人类在预防感染或延缓疾病方面的作用 进步。实际上，这个项目的研究人员将 描述了第三种对艾滋病毒的遗传耐药性，增加了 HL A/TAP复合体与趋化因子受体基因多态性

DESCRIPTION (adapted from the Abstract): This is project to continue the study of host genetic resistance to HIV-1. The project evolved from early studies which showed that CD4 lymphocytes from random individuals possessed differential susceptibility to certain strains of T cell- trophic HIV. This appeared to be genetically determined because the susceptible or resistant phenotype was consistent for a given donor and a given HIV strain, and because it segregated in a family. Two years of work have demonstrated further that this differential susceptibility is genetically determined as judged by more family segregation studies, and that it appears to be a unique resistance which is a post-entry restriction of the virus and is not receptor-mediated. Other studies during this period have shown, also, that two cases of "transient" HIV infection in adults are associated with this host lymphocyte resistance. Two new cohorts of high-risk individuals have been established and are currently under study to determine the frequency of transient infection and if host genetic resistance to T cell-trophic HIV strains is playing a role in both transient infection and in resistance to infection. The specific aims of the project: (1) to map the viral determinant of this host resistance; (2) to map the resistance genes in the human genome; and (3) to demonstrate further whether these genes have a role in the human population in either preventing infection or retarding disease progression. In effect, the researchers in this project will characterize a third type of genetic resistance to HIV, adding to the HLA/TAP complex and the chemokine receptor polymorphisms.