ANTIVIRAL AGENTS EFFECTS ON IMMUNE FUNCTIONS

描述：（改编自申请人摘要）申请人建议 利用猫免疫缺陷病毒（FIV）猫动物模型用于AIDS， 更好地理解慢病毒介导的 胸腺退化和胸腺损伤，以及胸腺的贡献 在慢病毒感染的受试者中，淋巴细胞生成对免疫稳态的影响。 的 小儿FIV模型显示淋巴结和胸腺病变类似于 在人类儿科艾滋病中的报告。 FIV感染的儿童和成年猫 也会丧失记忆抗原应答。 在他们的实验室工作 提示在小儿猫急性期抗病毒药物治疗 感染可以防止T细胞的损失可能通过保护胸腺 生命早期的淋巴细胞生成。 此外，他们有证据表明， 在FIV感染成年猫的初步研究中， 刺激胸腺造血的模式与恢复兼容， 胸腺T细胞加工 为此，他们提出以下建议 具体目标：1. 为了测量胸腺淋巴细胞生成对 a）维持外周血T淋巴细胞稳态; B） 补充由FIV感染消耗的T辅助细胞，和c） 在FIV感染期间丧失的回忆抗原应答的再生。 2)到 确定抗病毒治疗是否可以：a）防止胸腺退化和丧失 FIV感染的幼猫的胸腺淋巴细胞生成; B）允许 重建胸腺淋巴细胞生成和恢复记忆 FIV感染的成年猫的抗原T细胞反应。

DESCRIPTION: (Adapted from applicant's abstract) The applicants propose to utilize the feline immunodeficiency virus (FIV) cat animal model for AIDS to develop a better understanding of the pathogenesis of lentivirus-mediated thymic involution and thymic impairment, and the contribution of thymic lymphopoiesis to immune homeostasis in lentivirus-infected subjects. The pediatric FIV model shows lymph node and thymic lesions similar to those reported in human pediatric AIDS. FIV-infected pediatric and adult cats also have loss of recall antigen responses. Work in their laboratory suggest that in pediatric cats antiviral drug therapy during the acute stage of infection can prevent the loss of T-cells possibly by protecting thymic lymphopoiesis during early life. Further they have evidence from preliminary studies in FIV-infected adults cats, that antiviral therapy stimulates thymic hematopoiesis in a pattern compatible with restoration of thymic T-cell processing. For this proposal, they submit the following specific aims: 1. To measure the contribution of thymic lymphopoiesis to a) the maintenance of peripheral blood T-lymphocyte homeostasis; b) replenishment of T-helper cells depleted by FIV infection and c) regeneration of recall antigen responses lost during FIV infection. 2) To determine if antiviral therapy can: a) prevent thymic involution and loss of thymic lymphopoiesis in FIV-infected pediatric cats; b) allow for reestablishment of thymic lymphopoiesis and restoration of the recall antigen T-cell response in FIV-infected adult cats.