ROCHESTER EPIDEMIOLOGY PROJECT

罗切斯特流行病学项目(REP)是一项医疗记录 联动制度，需要监督向居民提供的护理 明尼苏达州罗切斯特和奥姆斯特德县。这一独特的基于人口的数据 基础设施提供详细的住院和门诊医疗信息 向当地居民提供保健服务的人员的记录。这些信息 包含在这些记录中代表了数百个 流行病学研究提供了对疾病的频率、病因、 心脏病、中风、痴呆症、帕金森病的自然病史和结局 疾病、癌症、糖尿病、消化障碍、骨质疏松症、关节炎和 人口中的许多其他疾病。此外，此基础设施允许 进行这些研究的成本只有#年实现的一小部分 它的缺席。由于基础设施最初是为整个 1966年，出版了1198份出版物，其中378份是 最近4年。尽管梅奥诊所支持对诊断进行索引 和程序记录在自己的记录中，这对这个项目是免费的，正在进行中 需要外部支持来收集有关诊断和程序的信息 来自非Mayo提供者的信息并在患者处整合这些信息 水平。正是基础设施的这一部分使代表成为 基于人口的资源。具体地说，1)需要继续提供资金 通过继续识别个人身份来维护当前的基础设施 在当地护理提供者的记录中，继续收集医疗信息 关于奥姆斯特德县居民的事件数据，来自非梅奥护理和护理提供者 继续将有关医疗保健的信息添加到关系数据库 数据库；2)加强进行遗传研究的基础设施 通过收集家族史和家庭信息进行流行病学研究 当地居民的结构，开发生物标本清单 从奥姆斯特县居民那里收集并收集有关风险的信息 行为、体征和症状；3)增强逻辑和分析能力 对罗切斯特流行病学项目研究的总体支持。这些活动 对于继续支持庞大的流行病学机构来说是不可或缺的 来自梅奥的研究人员在这一人群中进行的研究 全国各地的诊所和其他中心，包括30项独立的研究 由美国国立卫生研究院通过上一批赠款提供资金。 尽管基础数据系统运行良好，但这些目标将使 申请者扩展这一研究基础设施的能力和 确保其未来的实用性。

The Rochester Epidemiology Project (REP) is a medical records linkage system that entails surveillance of the care delivered to the residents of Rochester and Olmsted County, Minnesota. This unique population-based data infrastructure provides access to the detailed inpatient and outpatient medical records of the providers of health care to local residents. The information contained in these records represents the foundation for hundreds of epidemiologic studies that provide insight into the frequency, etiology, natural history and outcomes of heart disease, stroke, dementia, Parkinson's disease, cancer, diabetes, digestive disorders, osteoporosis, arthritis and many other diseases in the population. Moreover, this infrastructure allows the conduct of these studies at a fraction of the cost that would be realized in its absence. Since the infrastructure was first organized for the entire population in 1966, 1198 publications have been generated, including 378 in the most recent 4 years. Although Mayo Clinic supports the indexing of diagnoses and procedures in its own records at no cost to this project, ongoing extramural support is needed to collect information on diagnoses and procedures from the non-Mayo providers and to integrate this information at the patient level. It is this portion of the infrastructure that makes the REP a population-based resource. Specifically, continued funding is needed for 1) maintaining the current infrastructure by continuing to identify individuals across the records of local providers of care, continuing to collect medical event data on Olmstead County residents from the non-Mayo providers of care and continuing the accession of information about medical care to the relational database; 2) enhancing the infrastructure for the conduct of genetic epidemiologic studies by collecting information on family history and family structure of local residents, developing an inventory of biological specimens collected from Olmsted County residents and collecting information on risk behaviors, signs and symptoms; and 3) enhancing the logistic and analytic support for Rochester Epidemiology Project studies generally. These activities are indispensable to the continued support of the large body of epidemiologic research that is being conducted in this population by investigators from Mayo Clinic and other centers throughout the country, including 30 separate studies funded by the National Institutes of Health through the previous grant period. Although the basic data system has worked well, these aims will allow the applicants to extend the capabilities of this research infrastructure and insure its future usefulness.