MURINE DEVELOPMENTAL BRAIN INJURY

描述：（根据申请人的描述改编）本修订版 申请描述了实验，在这些实验中， 结扎造成单侧脑缺氧缺血 一个颈总动脉，然后暴露于全身 由于吸入浓度降低的氧气而导致的缺氧。 期间 脑缺氧缺血的过程和之后， 将进行实验，以确定的性质和程度， 最终的组织损伤 具体的治疗干预也是 提出了 其他发育中的小鼠将受到兴奋性毒性损伤 通过在大脑的特定区域注射谷氨酸激动剂。 与缺氧-缺血研究一样，建议进行实验， 确定最终形态异常的程度 作为治疗干预的效果。

DESCRIPTION: (Adapted from applicant's description) This revised application describes experiments in which developing mice will be subjected to unilateral cerebral hypoxia-ischemia produced by ligation of one common carotid artery followed thereafter by exposure to systemic hypoxia by the inhalation of reduced concentrations of oxygen. During the course of and following the cerebral hypoxia-ischemia, specific experiments will be performed to ascertain the nature and extent of the ultimate tissue injury. Specific therapeutic interventions also are proposed. Other developing mice will be subjected to excitotoxic injury by the injection of glutamate agonists into selected areas of brain. As with the hypoxia-ischemia studies, experiments are proposed to ascertain the extent of the ultimate morphologic abnormalities as well as the effect of therapeutic interventions.