Directed differentiation of human embryonic stem cells to kidney progenitors

在澳大利亚，11.3%的死亡与慢性肾脏疾病有关，每年花费卫生系统10亿美元。成人肾脏中没有干细胞可以取代受损的肾脏滤器。我们的初步结果表明，我们可能能够从胚胎干细胞或诱导的多能细胞中制造出肾脏干细胞。在这个项目中，我们将优化所需的条件，并测试这些细胞形成新肾脏结构的能力。

In Australia, 11.3% of deaths are associated with chronic kidney disease, costing the health system >$1 billion per annum. No stem cell exists in the adult kidney that can replace damaged kidney filters. We have preliminary results suggesting we may be able to make kidney stem cells from embryonic stem cells or induced pluripotent cells. In this project, we will optimise the conditions required and test the ability of these cells to form new kidney structures.