Hyperactive mobile DNA in schizophrenia

精神分裂症患者的高度活跃的移动DNA

• 批准号: nhmrc : 1138795
• 负责人: Prof Ernst Wolvetang
• 金额: $ 49.06万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hyperactive-mobile-dna-schizophrenia/1318858
• 关键词: Hyperactive; mobile; DNA; schizophrenia

Schizophrenia affects 1 in 100 people, and yet its causes remain largely unclear. To improve understanding, treatment and management of the disease, the team performing this research will evaluate whether mobile DNA elements found in our genome are activated by stress and thereby alter how brain cells work in individuals affected by schizophrenia. They will also test whether mobile DNA can be blocked by drugs, perhaps revealing new strategies to treat the disease.

精神分裂症影响100人中的1人，但其原因在很大程度上仍不清楚。为了提高对这种疾病的理解、治疗和管理，进行这项研究的团队将评估我们基因组中发现的移动的DNA元件是否会被压力激活，从而改变精神分裂症患者脑细胞的工作方式。他们还将测试移动的DNA是否能被药物阻断，也许会揭示治疗这种疾病的新策略。