ORGANIZATION OF ANTICIPATORY POSTURAL ADJUSTMENTS

描述（改编自申请人摘要）：本提案将 研究中枢运动控制机制， 姿势中央控制的姿态是通过预期的 在计划的姿势扰动之前进行姿势调整（APA） 并通过预期纠正和补偿姿势来减少它们， 处理实际发生的平衡扰动的调整 因为预期性修正的效率不理想。 最近，首席研究员开发了一种实验性的 研究过程中预期姿势调整的范例 站立时自动释放负载。该范例允许 分离影响APA的三个主要因素：运动动作， 外部扰动的影响和姿势稳定性。六个假设 明确预期姿势调整的组织将是 在八个实验中测试。具体目标1将审查中央 APA的组织;具体目标2将独立调查 两个因素中的每一个的影响，运动动作和 预期姿势调整后的扰动。第3章将 探讨姿势不稳定对预期姿势的影响 调整。具体目标4将检验这种关系的效果 运动动作和预期姿势扰动之间的关系 调整。 我们认为，通过理解预期姿势的性质， 正常成年人的调整，将能够更好地理解 病理性患者姿势失控。临床 研究结果的应用将更准确地确定 传统康复策略的重点是改善 姿势缺陷患者的姿势控制。

DESCRIPTION (Adapted from the Applicant's Abstract): This proposal will investigate central motor control mechanisms that underlie maintenance of posture. Central control of posture is expressed through anticipatory postural adjustments (APAs) that precede planned postural perturbations and minimize them with anticipatory corrections, and compensatory postural adjustments that deal with actual perturbations of balance that occur because of the suboptimal efficiency of anticipatory corrections. Recently, the Principal Investigator has developed an experimental paradigm for the investigation of anticipatory postural adjustments during self-initiated releasing of a load while standing. The paradigm allows the separation of three major factors that influence APAs: motor action, the effects of external perturbations, and postural stability. Six hypotheses clarifying the organization of anticipatory postural adjustments will be tested in eight experiments. Specific aim 1 will examine the central organization of APAs; Specific aim 2 will independently investigate the effect of each of two factors, motor action and the magnitude of perturbation upon anticipatory postural adjustments. Specific Aim 3 will investigate the effect of postural instability on anticipatory postural adjustments. Specific aim 4 will examine the effect of the relation between motor action and perturbation on anticipatory postural adjustments. It is felt that by understanding the nature of the anticipatory postural adjustments in normal adults one will be better able to understand the loss of control of posture in patients with pathology. Clinical application of the results of the study will define more precisely the focus of conventional rehabilitation strategies aimed at improving postural control in people with postural deficits.