MICROVASCULAR VASOACTIVITY IN THE RENAL MEDULLA

描述：（改编自研究者摘要）这是一份修订版 这是第一个研究腺苷在调节血液中作用的奖项。 肾髓质的血流。 具体目标是审查 cAMP介导A1和A2激动剂对离体灌流血管直径的影响 2）确定肾缺血对肾血管的影响， 体内肾髓质中的腺苷水平和对髓质血流的影响; 3)确定钠饮食变化对肾腺苷的影响 水平和局部血流在肾脏和; 4）映射腺苷 肾髓质中的管状和血管结构中的受体亚型。 这些研究应有助于提供关于 腺苷在控制髓血流量和氧气输送， 肾髓质在排尿机制中起关键作用 浓度，钠和水的排泄，以及动脉 压力

DESCRIPTION: (Adapted from the Investigator's Abstract) This is a revised first award that will investigate the role of adenosine in regulating blood flow in the renal medulla. The specific aims are to examine the role of cAMP in mediating A1 and A2 agonists on the diameter of isolated perfused vasa recta capillaries; 2) to determine the effects of renal ischemia on adenosine levels in the renal medulla and on medullary blood flow in vivo; 3) to determine the effects of changes in sodium diet on renal adenosine levels and regional blood flow in the kidney and; 4) to map adenosine receptor subtypes in tubular and vascular structures in the renal medulla. These studies should contribute important new information regarding the role of adenosine in the control of medullary blood flow and oxygen delivery to the renal medulla which plays a critical role in the mechanism of urine concentration, sodium and water excretion, and the control of arterial pressure.