PTSD IN CHILDREN WITH BURNS--A LONGITUDINAL STUDY

描述（改编自申请人的摘要）：广泛，长期 本项目的目标是了解影响 创伤后症状的纵向过程中的样本， 孩子们经历了类似的创伤事件，急性烧伤。 本研究旨在确定各种生物心理社会因素的影响， 创伤后症状的出现和持续的变量， 因急性烧伤住院的儿童。 这样的知识可以帮助 早期识别PTSD "高危"儿童。 当前项目 建议评估100名7至17岁的儿童， 他们因急性烧伤住院治疗， 波士顿 烧伤后不久将对儿童和家庭进行评估， 将收集有关创伤后应激障碍的各种"危险因素"的数据。 这些数据包括家庭压力，医疗干预的压力， 自尊和严重的分离症状 儿童和家庭将 评估是否存在急性应激症状。 唾液皮质醇和 将评估MHPG以及淋巴细胞糖皮质激素受体。 孩子们将在三个月，一年和两年后重新评估 出院 在每一次评估中，儿童和 父母的创伤后症状，以及疼痛，身体 影像学、家庭压力、内科/外科治疗和神经内分泌 功能将被评估。 数据将使用创新的 Willett（1988）提出的检验纵向数据的方法。 的 每个孩子的创伤后症状的轨迹在两年内， 将绘制研究图。 多元回归分析将用于 确定所研究的变量影响过程的程度 这些症状。

DESCRIPTION (Adapted from applicant's abstract): The broad, long-term objectives of this proposed project are to understand variables influencing the longitudinal course of post-traumatic symptoms among a sample of children who have experienced a similar traumatic event, an acute burn. This study aims to determine the influence of a variety of biopsychosocial variables on the emergence and persistence of post-traumatic symptoms in children hospitalized with an acute burn. Such knowledge can facilitate the early identification of children "at risk" for PTSD. the current project proposes to evaluate 100 children between the ages of seven and seventeen who are hospitalized for an acute burn at the Shriners Burns Institute in Boston. Children and families will be evaluated shortly after the burn and data concerning a variety of "risk factors" for PTSD will be collected. Such data include family stress, the stress of medical intervention, self-esteem and acute dissociative symptoms. Children and families will be evaluated for the presence of acute stress symptoms. Salivary cortisol and MHPG, as well as lymphocyte glucocorticoid receptors, will be assessed. Children will be reassessed at three months, one year and two years after discharge from the hospital. At each of these assessments, child and parent's post-traumatic symptoms, as well as variables such as pain, body image, family stress, medical/surgical treatment, and neuroendocrine function will be evaluated. Data will be analyzed using an innovative approach to examining longitudinal data suggested by Willett (1988). The trajectories of each child's post-traumatic symptoms over the two years of the study will be plotted. Multiple regression analyses will be used to determine the degree to which the variables studied influence the course of these symptoms.