EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY

描述：（申请人的描述）在此续期申请中，我们寻求 支持发展和评价若干新教育 Oncology Thinking Cap（OncoTCap）是一种计算机系统， 提供广泛和高度灵活的癌症建模实验室， 一系列教育干预措施。 OncoTCap的核心是一对 模拟异质性肿瘤演变的计算引擎， 基于对生物学假设的经济描述。 群体可以 被观察到对癌症治疗的演变和反应，OncoTCap还包括 一组接口程序，支持教育工作者使用该系统， 实习生和研究人员。 这些接口可用于促进 了解癌症治疗的重要问题，并支持 假设生成 在我们最初赠款下完成的工作的基础上，我们准备 在OncoTCap的能力方面， 建模能力和新的或改进的界面。 反过来，这些扩张将， 使我们能够开发和评估新的和增强的癌症干预措施， 教育，以加强基础科学研究，临床研究， 在乎 新的教育干预计划结合癌症 教育工作者包括： 1. 专家界面和癌症信息基因在三个癌症中心的应用 癌症奖学金计划，以加速渗透，整合和 新的癌症生物学知识在研究和临床实践中的可用性; 2. 临床试验向导在某高等医学院校的应用 癌症选择性地传达药物的四个主要阶段的经验 发展; 3.在持续培训中使用患者接触界面 肿瘤住院医师计划，侧重于患者管理技能。

DESCRIPTION: (Applicant's Description) In this renewal application, we seek support for development and evaluation of several novel educational applications of the Oncology Thinking Cap (OncoTCap), a computer system that provides an extensive and highly flexible cancer modeling laboratory enabling a range of educational interventions. The heart of OncoTCap is a pair of computational engines that simulate the evolution of heterogeneous tumors, based on an economical description of biological assumptions. Populations can be observed to evolve and respond to cancer treatments, OncoTCap also includes a set of interface programs that support the system's use by educators, trainees, and researchers. These interfaces can be used to promote understanding of important issues of cancer treatment and to support hypothesis generation. Building on the work performed under our initial grant, we are poised to make highly significant expansions in OncoTCap's capabilities, in regard to modeling power and new or improved interfaces. The expansions will, in turn, allow us to develop and evaluate new and augmented interventions in cancer education to enhance basic science research, clinical research, and patient care. The new educational interventions planned in conjunction with cancer educators include: 1. Utilization of Expert Interface and Cancer Information Genie in three cancer fellowship programs to accelerate the penetration, integration and usability of new cancer biology knowledge in research and clinical practice; 2. Utilization of the Clinical Trial Wizard in a medical school advanced cancer selective to convey experience with four major stages of drug development; 3. Utilization of the Patient Encounter Interface in an ongoing training program for oncology residents, focused on patient management skills.