BREAST CANCER RISK--RESIDENTIAL ENVIRONMENT AND GENETICS

描述：(申请人描述) 乳腺癌风险：居住环境和遗传学 有证据表明，与工业化相关的环境因素可能 在乳腺癌病因学中占有重要地位。几乎没有人研究过 接近潜在的有毒工业场所是乳腺癌的危险因素。 我们建议进行一项病例对照研究，以检查居住地点 在成年生活中与乳腺癌风险的关系。这项研究的目的 1)调查与钢铁厂、化工厂的距离，以及 居住的其他工业场所为危险因素。的时间段 被审查的将是(1)在以下期间的主要住所 月经初潮和首次怀孕(如果有，否则为更年期)和(2)居住地 (S)10年前和20年前；2)检查估计的苯暴露和 以这些时间段内住宅暴露为风险因素的多环芳烃。 次要目标是：3)通过以下方式检查新陈代谢的遗传变异性 NQ01、GST M1-1、GST P1-1和CYP 1A1与这些暴露和 乳腺癌风险；4)评估所有成人住所与以下方面的关系 远离潜在的重要风险暴露(钢厂、化学品 工厂等)和风险；5)检查估计的苯暴露和 PAHs存在于整个成人生活和风险中。我们将使用正在进行的 伊利县和尼亚加拉县乳腺癌病例对照研究 约1000例意外、原发、经组织学证实的乳房 癌症和2000多名对照，年龄在35-79岁之间，与病例频率匹配。 在最初的研究中，大约75%的参与者生活在这些 处于月经初潮时的县。当时这些妇女的地址 他们的出生和月经初潮将使用地理信息进行地理编码 系统(GIS)。将收集有关位置的历史数据 潜在的重要工业用地。我们将计算赔率比和95 距离每个潜在类别的距离的百分比置信度区间 以及接触多环芳烃和苯的可能水平的指数 我们将检查按基因分层的类别中的风险。这是一个 独特且经济实惠的机会来检验潜在的假设 在相对稳定的居住环境中，公共卫生具有重要意义 人口。

DESCRIPTION: (Applicant's Description) Breast Cancer Risk: Residential Environment and Genetics There is evidence that environmental factors related to industrialization may be important in breast cancer etiology. There has been little study of proximity to potentially toxic industrial sites as breast cancer risk factors. We propose to conduct a case-control study to examine location of residence during adult life in relation to breast cancer risk. The aims of the study are: 1) To investigate distance from steel mills, chemical factories, and other industrial sites of the residence as risk factors. The time periods to be examined will be (1 ) the primary residence during the period between menarche and first pregnancy (if any, otherwise menopause) and (2) residence (s) 10 and 20 years ago; 2) To examine estimated exposure to benzene and to PAHs based on residential exposure during these time periods as risk factors. Secondary objectives are: 3) To examine genetic variability in metabolism by NQ01, GST M1-1 , GST P1-1 and CYP 1A1 in relation to these exposures and breast cancer risk; 4) To evaluate all adult residences in relation to distance from potentially important exposures (steel mills, chemical factories, etc.) and risk; 5) To examine estimated exposure to benzene and to PAHs during the entire adult life and risk. We will use data from an ongoing case-control study of breast cancer in Erie and Niagara Counties including approximately 1000 cases of incident, primary, histologically-confirmed breast cancer and more than 2000 controls, age 35-79, frequency-matched to cases. About 75 percents of participants in the original study lived in these counties at the time of their menarche. Addresses for the women at the time of their birth and at menarche will be geocoded using a Geographic Information System (GIS). Historical data will be collected regarding location of potentially important industrial sites. We will calculate odds ratios and 95 percents confidence intervals for distance from each category of potential exposure and for an index of probable level of exposure to PAHs and to benzene and we will examine risk within categories stratified on genotype. This is a unique and cost effective opportunity to examine a hypothesis of potentially great public health importance in a relatively residentially stable population.